2-甲基-1-苯基-1-丙醇合成路线 （共 136 条）
反应条件
1: chlorobenzene With naphthalene; sodium in tetrahydrofuran T=-78°C; Metallation; 1 h; 2: isobutyraldehyde in tetrahydrofuran T=-78 - 25°C; Alkylation; 3 h;
参考文献
Van Den Ancker, Tania R.; Love, Cameron J.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 21 p. 3520 - 3523
反应条件
4,4'-di-tert-butylbiphenyl; lithium; isopropyl alcohol; nickel dichloride in tetrahydrofuran T=20 - 76°C; Inert atmosphere; chemoselective reaction;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
Tetrahedron, 2009 , vol. 65, # 51 p. 10637 - 10643
反应条件
zinc(II) chloride in tetrahydrofuran T=0°C; Grignard addition;
参考文献
Chemical Communications, , vol. 46, # 15 p. 2674 - 2676
反应条件
[Ru(Ph2PNHCH2-C4H3S)(η6-benzene)Cl2]; potassium hydroxide T=82°C; 4 h; Inert atmosphere;
参考文献
Applied Organometallic Chemistry, , vol. 25, # 4 p. 270 - 275
反应条件
1: With 4-bromooctafluorobutanetriethoxysilane; diethylzinc; N,N-dimethyl-N'-(4-tert-butylphenyl)formamidine in tetrahydrofuran; hexane T=20 - 60°C; Inert atmosphere; 2: With sodium hydroxide in tetrahydrofuran; hexane; water T=0°C; 1 h;
参考文献
Enthaler, Stephan; Schroeder, Kristin; Inoue, Shigeyoshi; Eckhardt, Bjoern; Junge, Kathrin; Beller, Matthias; Driess, Matthias
European Journal of Organic Chemistry, 2010 , # 25 p. 4893 - 4901
反应条件
chromium dichloride; nickel dichloride in N,N-dimethyl-formamide T=25°C; Arylation; 5 h;
参考文献
Chen, Da-Wei; Ochiai, Masahito
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6804 - 6814
反应条件
lithium borohydride in tetrahydrofuran T=0°C; 24 h;
参考文献
Comins, Daniel L.; Herrick, James J.
Tetrahedron Letters, 1984 , vol. 25, # 13 p. 1321 - 1324
反应条件
titanium tetrachloride in dichloromethane T=-78 - -30°C;
参考文献
Tetrahedron, , vol. 48, # 27 p. 5587 - 5596
反应条件
in tetrahydrofuran; diethyl ether T=-78 - 0°C; 2 h;
参考文献
WO2004/22526 A1, ;
Page 65 ;
WO 2004/022526 A1
反应条件
1: iso-propylmagnesium bromide With trimethylsilyl-methylmagnesium chloride; lithium chloride; zinc(II) chloride in tetrahydrofuran; diethyl ether T=20°C; 0.75 h; Inert atmosphere; 2: benzaldehyde in tetrahydrofuran; diethyl ether T=0°C; 3 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 75, # 15 p. 5008 - 5016
