1-[(甲基磺酰基)甲基]-4-硝基苯合成路线 （共 13 条）
反应条件
hydrogenchloride; iron in water; N,N-dimethyl-formamide 0.5 h; Heating;
参考文献
Rewcastle; Baguley; Cain
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1231 - 1235
反应条件
palladium 10 on activated carbon in ethyl acetate P=2068.65 Torr; 3 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; Stafford, Jeffrey Alan
Patent: WO2003/106416 A2, 2003 ;
Location in patent: Page 48 ;
WO 03/106416 A2
参考文献
Ingold; Ingold; Shaw
Journal of the Chemical Society, 1927 , p. 818
参考文献
Blackburn; Challenger
Journal of the Chemical Society, 1938 , p. 1875
Full Text Show Details
I.G. Farbenind.
Patent: DE623883 , 1934 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 22, p. 1040
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=0°C;
参考文献
Sammond, Douglas M.; Nailor, Kristen E.; Veal, James M.; Nolte, Robert T.; Wang, Liping; Knick, Victoria B.; Rudolph, Sharon K.; Truesdale, Anne T.; Nartey, Eldridge N.; Stafford, Jeffrey A.; Kumar, Rakesh; Cheung, Mui
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 15 p. 3519 - 3523
反应条件
in ethanol
T=80°C; 2 - 3 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION; Stafford, Jeffrey Alan
Patent: WO2003/106416 A2, 2003 ;
Location in patent: Page 47-48 ;
WO 03/106416 A2
反应条件
in tetrahydrofuran
T=60°C; 4 h;
参考文献
Guan, Huiping; Laird, A. Douglas; Blake, Robert A.; Tang, Cho; Liang, Chris
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 187 - 190
反应条件
1: Na / ethanol
2: aq. H2O2 / acetic acid
View Scheme
参考文献
Russell,G.A.; Pecoraro,J.M.
Journal of the American Chemical Society, 1979 , vol. 101, p. 3331 - 3334
反应条件
sodium hydrogencarbonate in N,N-dimethyl acetamide; water
T=80°C; 3 h;
参考文献
Xu, Feng; Savary, Kimberly; Williams, J. Michael; Grabowski, Edward J. J.; Reider, Paul J.
Tetrahedron Letters, 2003 , vol. 44, # 6 p. 1283 - 1286
反应条件
nitric acid
T=-10 - -5°C;
参考文献
Ingold; Ingold; Shaw
Journal of the Chemical Society, 1927 , p. 818
