3-(苄氧基)-2-甲基-4H-吡喃-4-酮合成路线 （共 23 条）
反应条件
1: NaOH / H2O; ethanol / 144 h / Ambient temperature 2: 8.04 g / conc. HCl View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 37, # 10 p. 1099 - 1102
反应条件
1: NaOH / ethanol; H2O / 12 h / pH 13.5 / Heating 2: H2 / Pd/C / ethanol; H2O / 2 h View Scheme
参考文献
Faerber, M.; Osiander, H.; Severin, T.
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 947 - 956
反应条件
1: 74 percent / ethanol; H2O / 10 h / Heating 2: 82 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature View Scheme
参考文献
Kontoghiorghes; Sheppard; Chambers
Arzneimittel-Forschung/Drug Research, 1987 , vol. 37, # 10 p. 1099 - 1102
反应条件
1: sodium hydroxide / ethanol; water / 18 h / 105 °C / pH 7 2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / ethanol; water / 4 h / 3000.3 Torr / pH 1 View Scheme
参考文献
Andayi, Warren A.; Egan, Timothy J.; Gut, Jiri; Rosenthal, Philip J.; Chibale, Kelly
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 7 p. 642 - 646
反应条件
sodium hydroxide in ethanol; water 18 h; Heating;
参考文献
University of Utah Research Foundation
Patent: US2006/30619 A1, 2006 ;
Location in patent: Page/Page column 18 ;
反应条件
1: 60 percent / NH3 / ethanol 2: 82 percent / HBr / acetic acid View Scheme
参考文献
Nelson, William O.; Karpishin,Timothy B.; Rettig, Steven J.; Orvig, Cris
Canadian Journal of Chemistry, 1988 , vol. 66, p. 123 - 131
反应条件
1: methanol / 48 h / Ambient temperature 2: conc. HCl / 0.5 h / Heating View Scheme
参考文献
Nelson, William O.; Karpishin,Timothy B.; Rettig, Steven J.; Orvig, Cris
Canadian Journal of Chemistry, 1988 , vol. 66, p. 123 - 131
反应条件
1: ethanol, NH4OH / Heating
2: 1.) hexamethyldisilazane, ammonium sulfate, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) reflux, 2 h, 2.) CH3CN, RT, 24 h
3: 0.98 g / H2 / Pd black / methanol / 760 Torr
View Scheme
参考文献
Mao, David T.; Driscoll, John S.; Marquez, Victor E.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 160 - 164
反应条件
sodium hydroxide; N-methylamine hydrochloride in ethanol; water
参考文献
National Research Development Corporation
Patent: US4550101 A1, 1985 ;
反应条件
in ethanol
22 h; Ambient temperature;
参考文献
Rumbo, Antonio; Mourino, Antonio; Castedo, Luis; Mascarenas, Jose L.
Journal of Organic Chemistry, 1996 , vol. 61, # 18 p. 6114 - 6120
