8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃合成路线 （共 6 条）
反应条件
titanium tetrachloride in 1,4-dioxane
24 h; Heating;
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
反应条件
1: With 1-chloroethyl chlorocarbonate in 1,2-dicholoroethane
T=0°C; 22.5 h; Inert atmosphereReflux;
2: With methanol
T=50°C; 2 h; Inert atmosphere;
参考文献
McRobb, Fiona M.; Crosby, Ian T.; Yuriev, Elizabeth; Lane, J. Robert; Capuano, Ben
Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1622 - 1634
反应条件
1: 74 percent / K2CO3; Cu / various solvent(s) / 4 h / Heating
2: 64 percent / Na2S2O4 / aq. NH3 / 80 °C
3: 79 percent / xylene / 96 h / Heating
4: 69 percent / TiCl4 / dioxane / 24 h / Heating
View Scheme
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
反应条件
1: 79 percent / xylene / 96 h / Heating
2: 69 percent / TiCl4 / dioxane / 24 h / Heating
View Scheme
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
反应条件
1: 64 percent / Na2S2O4 / aq. NH3 / 80 °C
2: 79 percent / xylene / 96 h / Heating
3: 69 percent / TiCl4 / dioxane / 24 h / Heating
View Scheme
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
反应条件
1: 74 percent / K2CO3; Cu / various solvent(s) / 4 h / Heating
2: 64 percent / Na2S2O4 / aq. NH3 / 80 °C
3: 79 percent / xylene / 96 h / Heating
4: 69 percent / TiCl4 / dioxane / 24 h / Heating
View Scheme
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
