2,2-二甲基-4-氧代戊醛合成路线 （共 16 条）
反应条件
potassium hydroxide in tetrahydrofuran; diethyl ether 48 h; Heating;
参考文献
Magnus, P. D.; Nobbs, M. S.
Synthetic Communications, 1980 , vol. 10, # 4 p. 273 - 278
反应条件
oxygen; copper(l) chloride; palladium dichloride in water; N,N-dimethyl-formamide
1 h; Ambient temperature;
参考文献
Magnus, P. D.; Nobbs, M. S.
Synthetic Communications, 1980 , vol. 10, # 4 p. 273 - 278
反应条件
(cetyl)Me3N(1+)MnO4(1-); triethylamine in dichloromethane
5.5 h;
参考文献
Vankar, Padma S.; Rathore, R.; Chandrasekaran, S.
Synthetic Communications, 1987 , vol. 17, # 2 p. 195 - 202
反应条件
1: 98 percent / Dibal-H / pentane / 3 h / -78 - 20 °C
2: PdCl2; CuCl; O2 / dimethylformamide; H2O / 72 h
View Scheme
参考文献
Yang, Jiong; Long, Yun Oliver; Paquette, Leo A.
Journal of the American Chemical Society, 2003 , vol. 125, # 6 p. 1567 - 1574
反应条件
sulfuric acid; mercuric sulphate
参考文献
Stevens; Cherpeck; Harrison; Lai; Lapalme
Journal of the American Chemical Society, 1976 , vol. 98, # 20 p. 6317 - 6321
反应条件
in diethyl ether
Irradiation;
参考文献
Urry,W.H. et al.
Journal of the American Chemical Society, 1970 , vol. 92, p. 5785 - 5787
反应条件
dimethylsulfide; methyllithium; oxygen; ozone
1.) benzene, ice bath, 4 h; 2.) CH2Cl2, -78 deg C; 3.) CH2Cl2, room temperature overnight; Yield given. Multistep reaction;
参考文献
Hudlicky; Luna; Barbieri; Kwart
Journal of the American Chemical Society, 1988 , vol. 110, # 14 p. 4735 - 4741
反应条件
1: 76 percent / sodium ethoxide / ethanol / 36 h / 80 °C
2: 1) KOH, 2) potassium permanganate, magnesium sulphate / 1) methanol, 25 deg C, 2h, 2) water, 1h, pH= 7
View Scheme
参考文献
Lui, Kon-Hung; Sammes, Michael P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 457 - 468
反应条件
diisobutylaluminium hydride; lithium diisopropyl amide
1.) THF, -78 deg C; 2.) -78 to -20 deg C; Yield given. Multistep reaction;
参考文献
Kraus, George A.; Frazier, Kevin
Journal of Organic Chemistry, 1980 , vol. 45, # 21 p. 4262 - 4263
反应条件
oxygen; ozone; triphenylphosphine
1.) MeOH, CH2Cl2, -60 deg C, 2.) RT, 5 h; Yield given. Multistep reaction;
参考文献
Srikrishna, Adusumilli; Kumar, P. Praveen; Viswajanani, Ranganathan
Tetrahedron Letters, 1996 , vol. 37, # 10 p. 1683 - 1686
