4-(3,4-二甲氧基苯基)-4-氧丁酸合成路线 （共 11 条）
反应条件
hydrogenchloride 0.5 h; Heating;
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
potassium hydroxide
48 h; Ambient temperature;
参考文献
Cragg, John E.; Herbert, Richard B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2487 - 2490
反应条件
potassium hydroxide
T=20°C; 24 h;
参考文献
Sharma, Vedula M.; Adi Seshu; Vamsee Krishna; Prasanna; Chandra Sekhar; Venkateswarlu; Rajagopal, Sriram; Ajaykumar; Deevi, Dhanvanthri S.; Rao Mamidi; Rajagopalan
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1679 - 1682
反应条件
1: 86 percent / sodium acetate / aq. ethanol / 6 h / Heating
2: 67 percent / aq. KOH / 40 h / Ambient temperature
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: 1.) sodium wire / 1) ether; 2) ether, reflux, 5 h
2: 86 percent / sodium acetate / aq. ethanol / 6 h / Heating
3: 67 percent / aq. KOH / 40 h / Ambient temperature
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: 98 percent / oxalyl chloride / benzene; dimethylformamide / 2 h / Ambient temperature
2: 1.) sodium wire / 1) ether; 2) ether, reflux, 5 h
3: 86 percent / sodium acetate / aq. ethanol / 6 h / Heating
4: 67 percent / aq. KOH / 40 h / Ambient temperature
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
(i) nBuLi, (ii) /BRN= 783596/, (iii) aq. H2SO4; Multistep reaction;
参考文献
Barnick,J.W.F.K. et al.
Synthesis, 1979 , p. 787 - 788
反应条件
diamine oxidase; catalase
T=27°C; 24 h; pH 7.0;
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
phosphate buffer in methanol; water
1 h;
参考文献
Mangla, V. K.; Bhakuni, D. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 9 p. 748 - 749
反应条件
in methanol; phosphate buffer
pH=7;
参考文献
Kimball, F. Scott; Tunoori, Ashok Rao; Victory, Samuel F.; Dutta, Dinah; White, Jonathan M.; Himes, Richard H.; Georg, Gunda I.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4703 - 4707
