1-甲基-1,2,4-三唑合成路线 （共 29 条）
反应条件
in dimethylsulfoxide-d6; water T=35°C;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1209 - 1216
参考文献
Gazzetta Chimica Italiana, , vol. 35 I, p. 386
反应条件
Ambient temperatureIrradiationphotochemistry of other N-(benzoylimino)-1,2,4-triazolium and N-(benzoylomino)pyridinium ylides; Mechanism;
参考文献
Journal of Organic Chemistry, , vol. 57, # 12 p. 3316 - 3319
反应条件
triethylamine in dichloromethane Ambient temperature;
参考文献
Matsumoto, Toyomi; Toyooka, Kouhei; Nishiwaki, Eiji; Shibuya, Masayuki
Heterocycles, 1990 , vol. 31, # 9 p. 1629 - 1633
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=-20 - 20°C;
参考文献
Geraschenko, Oleksandr V.; Khodakovskiy, Pavel V.; Shishkin, Oleg V.; Mykhailiuk, Pavel K.; Zaporozhets, Olga A.; Tolmachev, Andrey A.
Synthesis, 2011 , # 10 art. no. Z17811SS, p. 1633 - 1637
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78°C; 0.75 h; 2: With 1,2-dibromo-1,1,2,2-tetrafluoroethane in tetrahydrofuran T=20°C; 2 h; 3: With water; ethyl acetate more than 3 stages;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/102194 A1, 2006 ;
Location in patent: Page/Page column 117-118 ;
WO 2006/102194 A1
反应条件
potassium phosphate; palladium diacetate in 1-methyl-pyrrolidin-2-one
T=125°C; 24 h;
参考文献
Chiong, Hendrich A.; Daugulis, Olafs
Organic Letters, 2007 , vol. 9, # 8 p. 1449 - 1451
反应条件
1: 1-methyl-1H-1,2,4-triazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Inert atmosphere;
2: carbon dioxide in tetrahydrofuran; hexane
T=-78 - 20°C;
3: With water in tetrahydrofuran; hexane
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/147188 A1, 2009 ;
Location in patent: Page/Page column 99 ;
WO 2009/147188 A1
反应条件
potassium phosphate; copper(l) iodide; 1,10-phenanthroline; iodine; lithium tert-butylate in 1,4-dioxane
T=110°C; 2 h; Inert atmosphere; regioselective reaction;
参考文献
Do, Hien-Quang; Daugulis, Olafs
Journal of the American Chemical Society, 2011 , vol. 133, # 34 p. 13577 - 13586
