2,3-二氢吡啶并[2,3-d][1,3]噁唑-2-酮合成路线 （共 30 条）
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; COME, Jon; COTTRELL, Kevin; GREY, Ronald; LE TIRAN, Amaud; MARONE, Valerie; MARTINEZ-BOTELLA, Gabriel; MESSERSMITH, David; HUCK, Emilie, Porter
Patent: WO2010/135014 A1, 2010 ;
Location in patent: Page/Page column 50-51 ;
WO 2010/135014 A1
反应条件
1: 2-amino-3-hydroxy-pyridine With 5 rhodium-on-charcoal; hydrogen; acetic acid T=20°C; P=3375.34 Torr; 16 h; 2: 1,1'-carbonyldiimidazole With 4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 24 h; Overall yield = 753.0 mg;
参考文献
US2014/113824 A1, ;
Paragraph 0293-0295; 0300-0303 ;
反应条件
potassium hydroxide; selenium in N,N-dimethyl-formamide T=110°C; P=760 Torr; 4 h;
参考文献
Wang, Xiaofang; Ling, Gang; Xue, Yan; Lu, Shiwei
European Journal of Organic Chemistry, 2005 , # 8 p. 1675 - 1679
反应条件
potassium hydroxide; [bis(acetoxy)iodo]benzene in methanol T=0°C; 1 h;
参考文献
Prakash; Batra; Kaur; Sharma; Singh; Moriarty
Synthesis, 2001 , # 4 p. 541 - 543
反应条件
pyridine in 1,2-dichloro-ethane 3 h; Reflux;
参考文献
Qian, Jian-Qiang; Yan, Pu-Cha; Che, Da-Qing; Zhou, Qi-Lin; Li, Yuan-Qiang
Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1528 - 1531
反应条件
in acetonitrile 8 h; Ambient temperature;
参考文献
Takeda, Kazuyoshi; Ogura, Haruo
Synthetic Communications, 1982 , vol. 12, # 3 p. 213 - 218
反应条件
selenium 1.) DMSO, 31 kg/cm2, 100 degC, 20 h, 2.) 25 degC, 1 h;
参考文献
Yoshida, Tohru; Kambe, Nobuaki; Ogawa, Akiya; Sonoda, Noboru
Phosphorus and Sulfur and the Related Elements, 1988 , vol. 38, p. 137 - 148
反应条件
in acetonitrile 12 h;
参考文献
Takeda, Kazuyoshi; Tsuboyama, Kanoko; Takayanagi, Hiroaki; Shirokami, Rie; Takeura, Masumi; Ogura, Haruo
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2334 - 2337
反应条件
1: T=135 - 140°C; Condensation; 4 h; 2: With hydrogenchloride T=20°C; Cyclization; 16 h;
参考文献
Aliev; Tashkhodzbaev; Levkovich; Abdullaev; Kartstev
Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 11 p. 1337 - 1340
反应条件
1: With potassium hydroxide in ethanol; water 2: With potassium permanganate; acetic acid Further stages.;
参考文献
Phytochemistry, , vol. 66, # 15 p. 1797 - 1803
