1,3-二甲基-2-碘苯合成路线 （共 73 条）
反应条件
1: With copper(l) iodide; 2-methyl-8-hydroxyquinoline; tetra(n-butyl)ammonium hydroxide in water; dimethyl sulfoxide T=100°C; 10 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide T=20°C;
参考文献
Paul, Rajesh; Ali, Md Ashif; Punniyamurthy, Tharmalingam
Synthesis, 2010 , # 24 art. no. P11610SS, p. 4268 - 4272
反应条件
potassium permanganate
参考文献
Gilman; Stuckwisch
Journal of the American Chemical Society, 1943 , vol. 65, p. 1729,1731, 1732
反应条件
1: lithium 2: oxalic acid View Scheme
参考文献
Carlin; Landerl
Journal of the American Chemical Society, 1953 , vol. 75, p. 3969,3971
反应条件
(i) Mg, EtBr, I2, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Thomas,J.; Canty,J.
Journal of Pharmacy and Pharmacology, 1962 , vol. 14, p. 587 - 596
参考文献
Kohlrausch; Pongratz
Monatshefte fuer Chemie, 1934 , vol. 64, p. 361,364, 365
Monatshefte fuer Chemie, 1935 , vol. 65, p. 6,14
参考文献
Raaen,V.F.; Eastham,J.F.
Journal of the American Chemical Society, 1960 , vol. 82, p. 1349 - 1352
反应条件
1: lithium; diethyl ether / anschliessend Behandeln mit Acetaldehyd 2: activated Al2O3 / 270 - 280 °C / 10 Torr 3: KMnO4; aqueous KOH / Erwaermen des Reaktionsprodukts mit H2SO4, Aethanol und Benzol View Scheme
参考文献
Schwartzman; Corson
Journal of the American Chemical Society, 1954 , vol. 76, p. 781,783
反应条件
2: SOCl2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 82, p. 1349 - 1352
反应条件
1.1: 94 percent / Pd(OAc)2; Et3N; (2-MeC6H4)3P / acetonitrile / 24 h / Heating 2.1: 99 percent / 1 M aq. NaOH / dioxane / 2 h / 20 °C 3.1: H2 / 10 percent Pd/C / ethyl acetate / 70 °C / 3040 Torr 4.1: Et3N; DCC; HOBt / dimethylformamide / 5 h / 0 - 20 °C 5.1: conc. HCl / 8 h / Heating 5.2: H2O / pH 4 - 6 View Scheme
参考文献
Sasaki, Yusuke; Hirabuki, Mariko; Ambo, Akihiro; Ouchi, Hidekazu; Yamamoto, Yutaka
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 3 p. 327 - 329
反应条件
palladium diacetate; potassium carbonate; triphenylphosphine; copper(l) iodide in tetrahydrofuran Suzuki-Miyaura cross-coupling reaction; Heating;
参考文献
Hodgson, Paul B.; Salingue, Fabrice H.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 685 - 687
