4,5,6,7-四氢-1H-吲唑-3-甲酸合成路线 （共 10 条）
反应条件
water; sodium hydroxide in ethanol T=120°C; 1 h; Microwave irradiationSealed tube;
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 18 h;
参考文献
Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951
反应条件
1: N2H4*H2O; AcOH / 8 h / Heating 2: 53 percent / aq. NaOH / dioxane / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 18 p. 3945 - 3951
反应条件
1: EtONa / ethanol / 18 h / 20 °C 2: N2H4*H2O; AcOH / 8 h / Heating 3: 53 percent / aq. NaOH / dioxane / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 18 p. 3945 - 3951
反应条件
1.1: NH2NH2•xH2O / ethanol / |Reflux 1.2: 0.02 h / |Reflux 2.1: sodium hydroxide; water / ethanol / 1 h / 120 °C / |Microwave irradiation; |Sealed tube View Scheme
参考文献
Tetrahedron, , vol. 69, # 1 p. 257 - 263
反应条件
1.1: triethylamine / dichloromethane / 0 - 20 °C 1.2: 0 °C / |Reflux 2.1: sodium hydroxide; water / ethanol / 1 h / 120 °C / |Microwave irradiation; |Sealed tube View Scheme
参考文献
Tetrahedron, , vol. 69, # 1 p. 257 - 263
反应条件
dihydrogen peroxide in sodium hydroxide; ethanol T=50°C; 6 h; Radziszewski reaction; oxydative cleavage of nitriles to lower homologue acid acids; Product distribution;
参考文献
Tetrahedron Letters, , vol. 24, # 13 p. 1385 - 1386
参考文献
Justus Liebigs Annalen der Chemie, , vol. 453, p. 228
参考文献
Justus Liebigs Annalen der Chemie, , vol. 453, p. 228
参考文献
Justus Liebigs Annalen der Chemie, , vol. 453, p. 234
