1: thien-2-yl bromide With iodine; magnesium in tetrahydrofuran 2: With zinc(II) chloride in tetrahydrofuran T=0°C; 3: 2-Iodo-benzoic acid ethyl ester With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran Negishi coupling; 12 h;

1: 2-thienylmagnesium chloride With N,N,N',N,-tetramethylethylenediamine; zinc(II) chloride in tetrahydrofuran T=80°C; 0.25 h; microwave irradiation; 2: bromobenzoic acid ethyl ester With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=80°C; Negishi cross-coupling; 0.0333333 h; microwave irradiation;