sodium hydroxide in dichloromethane; water 4 h; Ambient temperature;

1: NaBH4 / dioxane; H2O / 1 h / Ambient temperature 2: KOH / diethyl ether; H2O / 0.5 h / Heating 3: NH3 / ethanol / 120 h / Ambient temperature 4: 50 percent / NaOH / CH2Cl2; H2O / 4 h / Ambient temperature View Scheme

1: NH3 / ethanol / 120 h / Ambient temperature 2: 50 percent / NaOH / CH2Cl2; H2O / 4 h / Ambient temperature View Scheme

1: 1-(2',5'-dimethoxyphenyl)-2-aminoethanol hydrochloride With potassium hydroxide in dichloromethane; water T=5 - 10°C; 0.25 h; 2: chloroacetyl chloride T=25 - 30°C; pH=3 - 6; 1 h;