1-甲基-1H-吲哚-2-甲腈合成路线 （共 17 条）
反应条件
diisobutylaluminium hydride in toluene T=-40 - 20°C; 16 h;
参考文献
Lin, Chih-Da; Fang, Jim-Min
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1993 , vol. 40, # 6 p. 571 - 580
反应条件
in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
Lin, Chih-Da; Fang, Jim-Min
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1993 , vol. 40, # 6 p. 571 - 580
反应条件
in diethyl ether T=-40 - 20°C; 16 h;
参考文献
Lin, Chih-Da; Fang, Jim-Min
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1993 , vol. 40, # 6 p. 571 - 580
反应条件
1: 1-methyl-1H-indole With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 2 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=0°C; 2 h;
3: With 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; ammonia in tetrahydrofuran; hexane; water
T=0 - 20°C; 4 h;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 5 p. 958 - 964
反应条件
1: 1H-Indole-2-carbonitrile With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 0.166667 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Xu, Shuguang; Huang, Xiaomei; Hong, Xiaohu; Xu, Bin
Organic Letters, 2012 , vol. 14, # 17 p. 4614 - 4617
反应条件
sodium methylate in tetrahydrofuran
16 h; Ambient temperature;
参考文献
Lin, Chih-Da; Fang, Jim-Min
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1993 , vol. 40, # 6 p. 571 - 580
反应条件
1.1: palladium diacetate; cupric trifluoroacetate; oxygen / N,N-dimethyl-formamide / 6 h / 130 °C
2.1: sodium ethanolate / dimethyl sulfoxide / 24 h / 110 °C / |Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C
3.2: 1 h / 20 °C
View Scheme
参考文献
Xu, Shuguang; Huang, Xiaomei; Hong, Xiaohu; Xu, Bin
Organic Letters, 2012 , vol. 14, # 17 p. 4614 - 4617
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: 24 h / 130 °C
2.1: palladium diacetate; cupric trifluoroacetate; oxygen / N,N-dimethyl-formamide / 6 h / 130 °C
3.1: sodium ethanolate / dimethyl sulfoxide / 24 h / 110 °C / |Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C
4.2: 1 h / 20 °C
View Scheme
参考文献
Xu, Shuguang; Huang, Xiaomei; Hong, Xiaohu; Xu, Bin
Organic Letters, 2012 , vol. 14, # 17 p. 4614 - 4617
反应条件
1.1: sodium ethanolate / dimethyl sulfoxide / 24 h / 110 °C / |Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C
2.2: 1 h / 20 °C
View Scheme
参考文献
Xu, Shuguang; Huang, Xiaomei; Hong, Xiaohu; Xu, Bin
Organic Letters, 2012 , vol. 14, # 17 p. 4614 - 4617
反应条件
in xylene
16 h; Heating;
参考文献
Fang, Jim-Min; Yang,Chau-Chen; Wang, Yu-Wen
Journal of Organic Chemistry, 1989 , vol. 54, # 2 p. 477 - 481
