3,3’,4’-三羟基黄酮合成路线 （共 7 条）
反应条件
hydrogenchloride; acetic acid
T=100°C; debenzylation;
参考文献
Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge
Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760
反应条件
1: 40 percent aq. KOH / dioxane; ethanol / 66 h / 20 °C
2: 5.4 percent aq. NaOH; 35 percent aq. H2O2 / dioxane; ethanol / 0 - 20 °C
3: 69 percent / 36 percent aq. HCl; glacial acetic acid / 100 °C
View Scheme
参考文献
Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge
Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760
反应条件
1: 40 percent aq. KOH / dioxane; ethanol / 66 h / 20 °C
2: 5.4 percent aq. NaOH; 35 percent aq. H2O2 / dioxane; ethanol / 0 - 20 °C
3: 69 percent / 36 percent aq. HCl; glacial acetic acid / 100 °C
View Scheme
参考文献
Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge
Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760
反应条件
1: 5.4 percent aq. NaOH; 35 percent aq. H2O2 / dioxane; ethanol / 0 - 20 °C
2: 69 percent / 36 percent aq. HCl; glacial acetic acid / 100 °C
View Scheme
参考文献
Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge
Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760
反应条件
hydrogen iodide
demethylation; Heating;
参考文献
Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba
Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210
反应条件
1: 6.0 g / 30 percent H2O2; NaOEt / ethanol / 0 - 20 °C
2: 44 percent / 57 percent aq. HI / Heating
View Scheme
参考文献
Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba
Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210
反应条件
1: NaOEt / ethanol
2: 6.0 g / 30 percent H2O2; NaOEt / ethanol / 0 - 20 °C
3: 44 percent / 57 percent aq. HI / Heating
View Scheme
参考文献
Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba
Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210
