2-氨基-3-硝基苯甲酸合成路线 （共 76 条）
参考文献
Gazzetta Chimica Italiana, , vol. 71, p. 481,485
Gazzetta Chimica Italiana, , vol. 80, p. 211,216
参考文献
Gazzetta Chimica Italiana, , vol. 71, p. 481,485
Gazzetta Chimica Italiana, , vol. 80, p. 211,216
反应条件
1: 66 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr 2: 77 percent / 4 M HCl / 1 h / Heating View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: With thionyl chloride in ethylene glycol dimethyl ether T=50°C; 12 h; 2: With ammonia; water T=50°C; 2 h;
参考文献
Giranda, Vincent L.; Penning, Thomas D.; Gandhi, Virajkamar B.; Thomas, Sheela A.; Zhu, Gui-Dong; Gong, Jianchun
Patent: US2007/259937 A1, 2007 ;
Location in patent: Page/Page column 11 ;
参考文献
Huntress; Gladding
Journal of the American Chemical Society, 1942 , vol. 64, p. 2644,2646
反应条件
hydrogen; palladium/active carbon in methanol P=3102.97 Torr; 18 h;
参考文献
Pfizer Inc
Patent: US2005/20626 A1, 2005 ;
Location in patent: Page 17-18 ;
US 20050020626 A1
反应条件
1: 2-methoxy-ethanol / 24 h / Heating 2: phosphorus oxychloride; phosphorus pentachloride; formamide / 3 h / Heating View Scheme
参考文献
VIFOR (INTERNATIONAL) AG
Patent: US2012/214803 A1, 2012 ;
US 20120214803 A1
反应条件
1: 66 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr 2: 72 percent / 4 M HCl / 1 h / Heating View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: thionyl chloride / ethylene glycol dimethyl ether / 12 h / 50 °C / |Large scale 2: ammonium hydroxide / 40 °C / |Large scale 3: hydrogen / water; ethanol; ethyl acetate / 1.67 h / 40 °C / 2828.7 Torr / |Cooling; |Large scale 4: hydrogenchloride / ethyl acetate / 30 °C / |Cooling; |Large scale 5: 1-methyl-pyrrolidin-2-one / 30 - 50 °C / |Large scale 6: acetic acid / water / 4 h / |Inert atmosphere; |Reflux; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 4 p. 693 - 698
反应条件
sodium dithionite in ethanol 1 h; Heating;
参考文献
Schmidt, Andreas; Gholipour Shilabin, Abbas; Nieger, Martin
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 23 p. 4342 - 4350
