2-氨基-3-硝基苯甲酸合成路线 （共 76 条）
反应条件
1: With potassium hydroxide; bromine in water T=-10 - 65°C; 1.41667 h; 2: With hydrogenchloride in water T=50 - 55°C;
参考文献
ABBOTT GMBH and CO. KG
Patent: WO2007/6566 A1, 2007 ;
Location in patent: Page/Page column 28; 33 ;
WO 2007/006566 A1
反应条件
ammonium hydroxide; copper(l) chloride T=125°C; 20 h;
参考文献
Mickelson, John W.; Jacobsen, E. Jon; Carter, Donald B.; Im, Haesook K.; Im, Wha Bin; Schreur, Peggy J. K. D.; Sethy, Vimala H.; Tang, Andy H.; McGee, James E.; Petke, James D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4654 - 4666
反应条件
1: With dihydrogen peroxide; sodium hydroxide in water T=20°C; Cooling with ice; 2: With citric acid in water
参考文献
Wang, Jingjing; Zuo, Sujing; Chen, Weiqiang; Zhang, Xinrui; Tan, Kaixin; Tian, Yun; Wang, Jianhui
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8217 - 8231
反应条件
1: With potassium hydroxide; bromine in water T=0 - 60°C; 15 h; 2: With hydrogenchloride in water
参考文献
NIPPON CHEMIPHAR CO., LTD.
Patent: EP1452528 A1, 2004 ;
Location in patent: Page 21 ;
反应条件
1: With sulfuric acid T=100°C; 1 h; 2: With ammonium hydroxide in water T=20°C; pH=3.0;
参考文献
Samumed, LLC; Hood, John; Kumar KC, Sunil; Wallace, David Mark
Patent: US2013/296302 A1, 2013 ;
Location in patent: Paragraph 0624 ;
反应条件
1: With copper(l) iodide; sodium azide; ethanol; caesium carbonate T=20 - 95°C; Inert atmosphereSealed tube; 2: With hydrogenchloride in water pH=2 - 3;
参考文献
Zhao, Haibo; Fu, Hua; Qiao, Renzhong
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3311 - 3316
反应条件
sodium hydroxide; sodium hypochlorite in water
参考文献
Aventis Pharma Deutschland GmbH
Patent: US6358978 B1, 2002 ;
反应条件
ammonium hydroxide in water
反应条件
hydrogenchloride in water 1 h; Heating;
参考文献
Nagasaka, Tatsuo; Koseki, Yuji
Journal of Organic Chemistry, 1998 , vol. 63, # 20 p. 6797 - 6801
反应条件
sodium hydroxide; bromine
