2-(4-甲基苯胺基)-2-苯基乙酸合成路线 （共 12 条）
反应条件
in acetonitrile
T=100°C; 1 h; microwave irradiation;
参考文献
CHIESI FARMACEUTICI S.P.A.; CALIGIURI, Antonio; RICCABONI, Mauro; AMARI, Gabriele
Patent: WO2010/72338 A1, 2010 ;
Location in patent: Page/Page column 214 ;
WO 2010/072338 A1
反应条件
chloro-trimethyl-silane; magnesium; triethylamine in N,N-dimethyl-formamide
T=20°C; P=34202.3 Torr; 24 h; Autoclave;
参考文献
Sathe, Ajay A.; Hartline, Douglas R.; Radosevich, Alexander T.
Chemical Communications, 2013 , vol. 49, # 44 p. 5040 - 5042
反应条件
hydrogenchloride
10 h; Heating;
参考文献
Csongar, Ch.; Mueller, I.; Slezak, H.; Klebsch, H.-J.; Tomaschewski, G.
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 6 p. 1006 - 1014
反应条件
1: 55 percent / H2O; ethanol / 1.) 1 h cooling; 2.) 20 h room temperature
2: 45 percent / conc. HCl / 10 h / Heating
View Scheme
参考文献
Csongar, Ch.; Mueller, I.; Slezak, H.; Klebsch, H.-J.; Tomaschewski, G.
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 6 p. 1006 - 1014
反应条件
1: 55 percent / H2O; ethanol / 1.) 1 h cooling; 2.) 20 h room temperature
2: 45 percent / conc. HCl / 10 h / Heating
View Scheme
参考文献
Csongar, Ch.; Mueller, I.; Slezak, H.; Klebsch, H.-J.; Tomaschewski, G.
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 6 p. 1006 - 1014
反应条件
1: alcohol; potassium cyanide
2: hydrochloric acid
View Scheme
参考文献
v. Miller; Ploechl
Chemische Berichte, 1896 , vol. 29, p. 1736
Chemische Berichte, 1898 , vol. 31, p. 2707,2708, 2711, 2716
反应条件
1: magnesium sulfate
2: magnesium; chloro-trimethyl-silane; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / 34202.3 Torr / |Autoclave
View Scheme
参考文献
Sathe, Ajay A.; Hartline, Douglas R.; Radosevich, Alexander T.
Chemical Communications, 2013 , vol. 49, # 44 p. 5040 - 5042
反应条件
1: magnesium sulfate
2: magnesium; chloro-trimethyl-silane; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / 34202.3 Torr / |Autoclave
View Scheme
参考文献
Sathe, Ajay A.; Hartline, Douglas R.; Radosevich, Alexander T.
Chemical Communications, 2013 , vol. 49, # 44 p. 5040 - 5042
参考文献
Stoeckenius
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1878 , p. 779
反应条件
T=120°C; im geschlossenen Rohr;
参考文献
v. Miller; Ploechl
Chemische Berichte, 1896 , vol. 29, p. 1736
Chemische Berichte, 1898 , vol. 31, p. 2707,2708, 2711, 2716
