4-羟基-1,6-二甲基-2(1H)-吡啶酮合成路线 （共 8 条）
反应条件
in water
3 h; Heatingmethylamine excess;
参考文献
Castillo, Simone; Ouadahi, Hamid; Herault, Valentin
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 7-8 p. 257 - 261
反应条件
1: 85 percent / toluene / 0.5 h / Heating
2: 86 percent / bis-(2-methoxy-ethyl) ether / 4 h / 160 °C
View Scheme
参考文献
Rubinov; Zheldakova; Rubinova
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 9 p. 1329 - 1331
反应条件
1: 82 percent / methanol; H2O / 10 h / 20 °C
2: 85 percent / toluene / 0.5 h / Heating
3: 86 percent / bis-(2-methoxy-ethyl) ether / 4 h / 160 °C
View Scheme
参考文献
Rubinov; Zheldakova; Rubinova
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 9 p. 1329 - 1331
反应条件
1: H2O / 1 h / Heating; 1/1 proportion
2: H2O / Heating
View Scheme
参考文献
Castillo, Simone; Ouadahi, Hamid; Herault, Valentin
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 7-8 p. 257 - 261
参考文献
Castillo, Simone; Ouadahi, Hamid; Herault, Valentin
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 7-8 p. 257 - 261
反应条件
in water
1 h; Heatingalso with other amines, vari. of reaction time; with proporton 1/1 gives hexanamides, with excess amines gives 4-hydroxy-6-methyl-2-pyridones; Product distributionMechanism;
参考文献
Castillo, Simone; Ouadahi, Hamid; Herault, Valentin
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 7-8 p. 257 - 261
反应条件
1: 58 percent / diphenyl ether / 2 h / Heating
2: 72 percent / aq. NaOH / ethane-1,2-diol / 2 h / Heating
View Scheme
参考文献
Khattab, Ahmed F.
Liebigs Annales, 1996 , # 3 p. 393 - 395
反应条件
in diphenylether
Heating;
参考文献
El-Essawy, Farag A.; Khattab, Ahmed F.; Zahran, Magdy A.; Gomaa, Sherif H.
Synthetic Communications, 2007 , vol. 37, # 18 p. 3225 - 3237
