2,3,4,9-四氢-1H-beta-咔啉-3-甲酸合成路线 （共 19 条）
反应条件
1: 85 percent / H2SO4 / Heating 2: 80 percent / MnO2 / benzene / Heating View Scheme
参考文献
Hagen, Timothy J.; Guzman, Filadelfo; Schultz, Christopher; Cook, James M.; Skolnick, Phil; Shannon, Harlan E.
Heterocycles, 1986 , vol. 24, # 10 p. 2845 - 2855
反应条件
selenium(IV) oxide; acetic acid 24 h; Heating;
参考文献
Hagen; Skolnick; Cook
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 750 - 753
反应条件
1: 70 percent / HCl (gas) 2: 35 percent / chloranil / various solvent(s) / 1.5 h / Heating View Scheme
参考文献
Hagen, Timothy J.; Guzman, Filadelfo; Schultz, Christopher; Cook, James M.; Skolnick, Phil; Shannon, Harlan E.
Heterocycles, 1986 , vol. 24, # 10 p. 2845 - 2855
反应条件
hydrogenchloride Heating; Yield given;
参考文献
Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al.
Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142
反应条件
in methanol; water T=25°C; 5 h; +1.0V/30mA; anode: graphite felt, cathode: Pt, electrolyte: KH2PO4/K2HPO4;
参考文献
Bobbitt, James M.; Willis, John P.
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1978 - 1984
反应条件
1: SOCl2
2: S / xylene; dioxane
View Scheme
参考文献
Hagen, Timothy J.; Guzman, Filadelfo; Schultz, Christopher; Cook, James M.; Skolnick, Phil; Shannon, Harlan E.
Heterocycles, 1986 , vol. 24, # 10 p. 2845 - 2855
反应条件
1.1: thionyl chloride / 24 h / -10 °C / Reflux
1.2: pH 8
2.1: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C
3.1: hydrazine hydrate / pentan-1-ol / 7 h / 150 °C
4.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
5.1: o-xylene / 1 h / 160 °C
6.1: water; potassium hydroxide / ethanol / 2 h / Reflux
View Scheme
参考文献
Lin, Guowu; Wang, Yue; Zhou, Qingfa; Wang, Jian; Yang, Taotao; Wang, Zhanwei; Lu, Tao
Synthetic Communications, 2012 , vol. 42, # 13 p. 1895 - 1910
反应条件
sulfur in xylene
Heating;
参考文献
Lippke; Schunack; Wenning; Muller
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 499 - 503
参考文献
Maclaren, John A.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 813 - 821
反应条件
1: 90 percent / HCl (gas)
2: 57 percent / AcOH, Pb(OAc)4 / 15 h
3: 1.) Na / 2.) 80 deg C
View Scheme
参考文献
Lippke; Schunack; Wenning; Muller
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 499 - 503
