1-β-D-阿拉伯呋喃糖苷胸腺嘧啶合成路线 （共 17 条）
反应条件
1: 93 percent / SnCl4 / 1,2-dichloro-ethane / 48 h / 20 °C 2: 80 percent / 1 N sodium methylate / methanol / 3 h / 20 °C 3: 1.) acetylsalicylic chloroanhydride, 2.) 0.5 N HCl / 1.) nitromethane, 20 deg C, 15 h, 2.) water, dioxane, 100 deg C, 2.5 h View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 6 p. 493 - 496
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 6 p. 699 - 702
反应条件
aufeinanderfolgende Behandlung des Reaktionsprodukts mit methanol.NH3 und mit wss.H2SO4;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 2775,2777
反应条件
1: Escherichia coli purine nucleoside phosphorylase 2: 45 percent / uridine phosphorylase 3: 1.) acetylsalicyloyl chloride, 2.) 0.5 N HCl / 2.) water, dioxane View Scheme
参考文献
Chemistry of Natural Compounds, , vol. 25, # 4 p. 504 - 505
反应条件
water; ammonium chloride; triphenylphosphine 1) THF, reflux, 12 h, 2) MeOH, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 2 p. 213 - 215
反应条件
water; ammonium chloride; triphenylphosphine 1) THF, reflux, 24 h, 2) MeOH, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 2 p. 213 - 215
反应条件
1: 45 percent / uridine phosphorylase 2: 1.) acetylsalicyloyl chloride, 2.) 0.5 N HCl / 2.) water, dioxane View Scheme
参考文献
Chemistry of Natural Compounds, , vol. 25, # 4 p. 504 - 505
反应条件
1: pyridine 2: pyridine / 24 h 3: 80percent aq. HCOOH / 4.5 h 4: 2,4,6-triisopropylbenzenesulfonyl chloride, pyridine / 1.) 25 deg C, 2.) room temperature, overnight 5: 2 M NaOH / 3 h / 25 °C View Scheme
参考文献
Lambert, Robert W.; Martin, Joseph A.; Thomas, Gareth J.; Duncan, Ian B.; Hall, Michael J.; Heimer, Edgar P.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 367 - 374
