N-[4-[[4-[(5-乙基-1,3,4-噻二唑-2-基)氨基磺酰基]苯基]氨基磺酰基]苯基]乙酰胺合成路线 （共 13 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=60°C; 11 h;
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1: 95 percent / imidazole / dimethylformamide / 3 h / 20 °C
2: 98 percent / K2CO3 / methanol / 2 h
3: PCC / CH2Cl2 / 1 h / 20 °C
4: K2CO3 / methanol / 1.5 h / 20 °C
5: 550 mg / LiAlH4 / diethyl ether / 3 h / 0 °C
6: CBr4; PPh3 / benzene / 2 h / 0 °C
7: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
8: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1: 550 mg / LiAlH4 / diethyl ether / 3 h / 0 °C
2: CBr4; PPh3 / benzene / 2 h / 0 °C
3: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
4: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1: K2CO3 / methanol / 1.5 h / 20 °C
2: 550 mg / LiAlH4 / diethyl ether / 3 h / 0 °C
3: CBr4; PPh3 / benzene / 2 h / 0 °C
4: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
5: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
2: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1: CBr4; PPh3 / benzene / 2 h / 0 °C
2: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
3: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1: PCC / CH2Cl2 / 1 h / 20 °C
2: K2CO3 / methanol / 1.5 h / 20 °C
3: 550 mg / LiAlH4 / diethyl ether / 3 h / 0 °C
4: CBr4; PPh3 / benzene / 2 h / 0 °C
5: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
6: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1: 98 percent / K2CO3 / methanol / 2 h
2: PCC / CH2Cl2 / 1 h / 20 °C
3: K2CO3 / methanol / 1.5 h / 20 °C
4: 550 mg / LiAlH4 / diethyl ether / 3 h / 0 °C
5: CBr4; PPh3 / benzene / 2 h / 0 °C
6: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
7: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1.1: AD-mix-β
1.2: MeSO2Cl; pyridine
2.1: Mn; 2,5,6-collidine; Me3SiCl / Cp2TiCl2 / tetrahydrofuran / 2 h / 20 °C
2.2: 47 percent / Bu4NF / tetrahydrofuran / 3 h
3.1: 95 percent / imidazole / dimethylformamide / 3 h / 20 °C
4.1: 98 percent / K2CO3 / methanol / 2 h
5.1: PCC / CH2Cl2 / 1 h / 20 °C
6.1: K2CO3 / methanol / 1.5 h / 20 °C
7.1: 550 mg / LiAlH4 / diethyl ether / 3 h / 0 °C
8.1: CBr4; PPh3 / benzene / 2 h / 0 °C
9.1: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
10.1: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
反应条件
1.1: Mn; 2,5,6-collidine; Me3SiCl / Cp2TiCl2 / tetrahydrofuran / 2 h / 20 °C
1.2: 47 percent / Bu4NF / tetrahydrofuran / 3 h
2.1: 95 percent / imidazole / dimethylformamide / 3 h / 20 °C
3.1: 98 percent / K2CO3 / methanol / 2 h
4.1: PCC / CH2Cl2 / 1 h / 20 °C
5.1: K2CO3 / methanol / 1.5 h / 20 °C
6.1: 550 mg / LiAlH4 / diethyl ether / 3 h / 0 °C
7.1: CBr4; PPh3 / benzene / 2 h / 0 °C
8.1: 75 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 20 °C
9.1: 90 percent / TBAF / tetrahydrofuran / 11 h / 60 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Arteaga, Jesus F.; Piedra, Maria; Sanchez, Elena M.
Organic Letters, 2005 , vol. 7, # 12 p. 2301 - 2304
