3-(4-氯苯基)-6-肼基哒嗪合成路线 （共 6 条）
反应条件
hydrogen; nickel in methanol T=20°C; P=760 Torr;
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
hydrazine hydrate in butan-1-ol
T=100°C; 6 h;
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C
2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
1: trichlorophosphate / 6 h / Heating
2: hydrazine hydrate / ethanol / 16 h / Reflux
View Scheme
参考文献
Islam, Mojahidul; Siddiqui, Anees A.
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 5 p. 555 - 562
反应条件
1: sodium acetate; hydrazine hydrate / methanol / 6 h / Reflux
2: trichlorophosphate / 6 h / Heating
3: hydrazine hydrate / ethanol / 16 h / Reflux
View Scheme
参考文献
Islam, Mojahidul; Siddiqui, Anees A.
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 5 p. 555 - 562
反应条件
1: AlCl3, aluminium chloride / Reflux
2: sodium acetate; hydrazine hydrate / methanol / 6 h / Reflux
3: trichlorophosphate / 6 h / Heating
4: hydrazine hydrate / ethanol / 16 h / Reflux
View Scheme
参考文献
Islam, Mojahidul; Siddiqui, Anees A.
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 5 p. 555 - 562
