8-甲氧基-1-甲基-2(1H)-喹啉酮合成路线 （共 7 条）
参考文献
Fischer,O.
Chemische Berichte, 1902 , vol. 35, p. 3682
反应条件
sodium hydroxide in water
Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/6648 A1, 2008 ;
Location in patent: Page/Page column 42-43 ;
反应条件
potassium hydroxide; potassium hexacyanoferrate(III) in diethyl ether; water
1.) 0 deg C, 2.) room temp., overnight;
参考文献
Gesto, C.; Cuesta, E. de la; Avendano, C.
Synthetic Communications, 1990 , vol. 20, # 1 p. 35 - 39
反应条件
toluene-4-sulfonic acid in toluene
21 h; Heating;
参考文献
Toda; Sakagami; Goan; Simakata; Saitoh; Horiguchi; Sano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1854 - 1861
反应条件
toluene-4-sulfonic acid in toluene
21 h; Heating;
参考文献
Toda; Sakagami; Goan; Simakata; Saitoh; Horiguchi; Sano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1854 - 1861
反应条件
1: 34 percent / tetrabutylammonium bromide / tetrahydrofuran / 3 h / 20 °C
2: 2 percent / p-TsOH*H2O / toluene / 21 h / Heating
View Scheme
参考文献
Toda; Sakagami; Goan; Simakata; Saitoh; Horiguchi; Sano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1854 - 1861
反应条件
aluminium trichloride in ice-water; nitrobenzene
参考文献
Otsuka Pharmaceutical Company Limited
Patent: US4022784 A1, 1977 ;
US 4022784 A
