(R)-(-)-1-(2-吡咯烷基甲基)吡咯烷合成路线 (共 7 条)
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 4 h; Heating;
参考文献
Costa, Brian R. de; Dominguez, Celia; He, Xiao-shu; Williams, Wanda; Radesca, Lilian; Bowen, Wayne
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4334 - 4343
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 17 h; Heating;
参考文献
Harrison; O'Brien
Synthetic Communications, 2001 , vol. 31, # 8 p. 1155 - 1160
反应条件
1: 70 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole (HOBT) / CH2Cl2 / Ambient temperature 2: 100 percent / TFA / CH2Cl2 / 0.83 h / Ambient temperature 3: 91 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4334 - 4343
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 20 p. 2229 - 2234
反应条件
1: PTSA / toluene / 16 h / Heating 2: acetonitrile / 0.17 h / 20 °C 3: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 20 p. 2229 - 2234
反应条件
1.1: s-butyllithium; (-)-sparteine / diethyl ether; cyclohexane / 5 h / -78 °C 1.2: diethyl ether; cyclohexane / 0.08 h / -78 °C 2.1: 56 percent / lithium aluminum hydride / tetrahydrofuran / 17 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 31, # 8 p. 1155 - 1160
反应条件
EDAC; triethanolamine; benzotriazol-1-ol in N,N-dimethyl-formamide