(1S,4R)-顺式-4-乙酰氧基-2-环戊烯-1-醇合成路线 （共 38 条）
反应条件
1: 50 percent / Et3N, pancreatin, vinyl acetate / various solvent(s) / 7 h / Ambient temperature 2: DMAP / pyridine / 16 h / Ambient temperature 3: p-TsOH / ethanol / 2 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 6 p. 1983 - 2004
反应条件
tetrakis(triphenylphosphine) palladium(0); triglyme (triethylene glycol dimethyl ether) in tetrahydrofuran T=0°C; 1 h; Schlenk techniqueInert atmosphere; Reagent/catalystSolvent; Overall yield = 85 percentChromat.;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 11-12 p. 2129 - 2134
反应条件
toluene-4-sulfonic acid in ethanol 2 h; Ambient temperature; Yield given;
参考文献
Tetrahedron, , vol. 53, # 6 p. 1983 - 2004
反应条件
1: DMAP / pyridine / 16 h / Ambient temperature 2: p-TsOH / ethanol / 2 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 6 p. 1983 - 2004
反应条件
potassium hydroxide; pig pancreatic lipase T=37°C; 8 h; 0.1 M phosphate buffer (pH 7); Yield given. Yields of byproduct given;
参考文献
Synthesis, , # 1 p. 19 - 22
反应条件
toluene-4-sulfonic acid in ethanol 2 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 53, # 6 p. 1983 - 2004
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / N,N-dimethyl-formamide / 16 h / 10 - 30 °C / Inert atmosphere 2: disodium hydrogenphosphate / water / 14 h / 25 - 30 °C / pH 7 / Enzymatic reaction View Scheme
反应条件
1: (R,R)-(-)-[N,N(1)-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminoat(2-)]manganese (III) chloride; 4-phenylpyridine-N-oxide; sodium hypochlorite / dichloromethane / 5 h / 4 °C 2: triglyme (triethylene glycol dimethyl ether); tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 1 h / 0 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 11-12 p. 2129 - 2134
反应条件
1: 99 percent / Et3N; DMAP 2: 82 percent / TBAF View Scheme
参考文献
Synlett, , # 14 p. 2558 - 2562
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 5 p. 1402 - 1408
