(1S,4R)-顺式-4-乙酰氧基-2-环戊烯-1-醇合成路线 （共 38 条）
反应条件
toluene-4-sulfonic acid in ethanol; ethyl acetate
参考文献
Hoechst Marion Roussel Inc.
Patent: US5728899 A1, 1998 ;
反应条件
lipase EC 3.1.1.3 L10 in water; acetone T=5 - 25°C; 6.5 h; Product distribution / selectivity;
参考文献
RHODIA-CHIMIE
Patent: US2008/39635 A1, 2008 ;
Location in patent: Page/Page column 4-5 ;
反应条件
Novosyme sp 435 lipase in various solvent(s) T=20°C; pH=8; 18 h;
参考文献
Tietze, Lutz F.; Brasche, Gordon; Grube, Alexander; Boehnke, Niels; Stadler, Christian
Chemistry - A European Journal, 2007 , vol. 13, # 30 p. 8543 - 8563
反应条件
porcine liver esterase; phosphate buffer T=37°C; Hydrolysis; pH=7.0; 48 h;
参考文献
Ogawa, Akira; Shuto, Satoshi; Tanaka, Motohiro; Sasaki, Takuma; Mori, Shuji; Shigeta, Shiro; Matsuda, Akira
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 7 p. 1000 - 1005
反应条件
triethylamine in tetrahydrofuran 2.5 h; Ambient temperaturePancreatin as lipase;
参考文献
Tetrahedron, , vol. 47, # 36 p. 7569 - 7582
反应条件
sodium hydroxide; Esterase(porcine liver)PLE in water T=32°C; 8 h; further enzymes; pH=7, phosphate buffer; Product distribution;
参考文献
Tetrahedron Letters, , vol. 25, # 51 p. 5875 - 5878
反应条件
tetrabutyl ammonium fluoride
参考文献
Gilbert, Michael W.; Galkina, Anna; Mulzer, Johann
Synlett, 2004 , # 14 p. 2558 - 2562
反应条件
1: 53 percent / KH2PO4, H3PO4 / H2O / 40 h / 99 °C / pH 4.1 2: 76 percent / PPTs / tetrahydrofuran / 18 h / Ambient temperature 3: LiAlH4, LiI / various solvent(s); toluene / 0.5 h / -20 - -13 °C 4: 50 percent / Et3N, pancreatin, vinyl acetate / various solvent(s) / 7 h / Ambient temperature 5: DMAP / pyridine / 16 h / Ambient temperature 6: p-TsOH / ethanol / 2 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 6 p. 1983 - 2004
反应条件
1: 76 percent / PPTs / tetrahydrofuran / 18 h / Ambient temperature 2: LiAlH4, LiI / various solvent(s); toluene / 0.5 h / -20 - -13 °C 3: 50 percent / Et3N, pancreatin, vinyl acetate / various solvent(s) / 7 h / Ambient temperature 4: DMAP / pyridine / 16 h / Ambient temperature 5: p-TsOH / ethanol / 2 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 6 p. 1983 - 2004
反应条件
1: LiAlH4, LiI / various solvent(s); toluene / 0.5 h / -20 - -13 °C 2: 50 percent / Et3N, pancreatin, vinyl acetate / various solvent(s) / 7 h / Ambient temperature 3: DMAP / pyridine / 16 h / Ambient temperature 4: p-TsOH / ethanol / 2 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 6 p. 1983 - 2004
