alpha-(氨基甲基)-2,5-二甲氧基苄醇盐酸盐合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=50°C; P=760 Torr;
参考文献
Epifani, E.; Lapucci, A.; Macchia, B.; Macchia, F.; Tognetti, P.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 254 - 259
反应条件
1: 93 percent / benzene / 5 h / Ambient temperature 2: 49 percent / NaBH4, 2 N aq. NaOH / methanol / 1 h / Ambient temperature 3: 67 percent / H2 / 10percent Pd/C / ethanol / 50 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 2 p. 254 - 259
反应条件
1: 49 percent / NaBH4, 2 N aq. NaOH / methanol / 1 h / Ambient temperature 2: 67 percent / H2 / 10percent Pd/C / ethanol / 50 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 2 p. 254 - 259
反应条件
hydrogenchloride; lithium aluminium tetrahydride 1.) THF, reflux, 2 h, 2.) methanol, ether; Yield given. Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 11 p. 881 - 888
反应条件
1: zinc iodide / 1 h / Ambient temperature 2: 1.) lithium aluminum hydride, 2.) HCl / 1.) THF, reflux, 2 h, 2.) methanol, ether View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 11 p. 881 - 888
反应条件
1: diisopropylethylamine; HOBt.H2O; WSCDI / dimethylformamide / 12 h / 20 °C
2: HCl / dioxane / 2 h / 20 °C
View Scheme
参考文献
Tsuda, Masahiro; Terada, Tomohiro; Irie, Megumi; Katsura, Toshiya; Niida, Ayumu; Tomita, Kenji; Fujii, Nobutaka; Inui, Ken-Ichi
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 318, # 1 p. 455 - 460
反应条件
1: 1-(2',5'-dimethoxyphenyl)-2-aminoethanol hydrochloride With potassium hydroxide in dichloromethane; water
T=5 - 10°C; 0.25 h;
2: chloroacetyl chloride T=25 - 30°C; pH=3 - 6; 1 h;
参考文献
Chemagis Ltd.
Patent: EP1234817 A1, 2002 ;
Location in patent: Example 1 ;
