3-(三氟甲基)-1H-1,2,4-噻唑合成路线 （共 2 条）
反应条件
1: ethyl-α,α,α-trifluoroacetate With hydrazine hydrate in methanol; ethanol T=0 - 20°C; 2: methanimidamide monoacetate in methanol; ethanol T=80°C; 2.5 h;
参考文献
WO2010/29461 A1, ;
Page/Page column 50-51 ;
WO 2010/029461 A1
反应条件
1: in ethanol T=20°C; 0.5 h; 2: With acetic acid T=100°C; 5 h;
参考文献
EP1710234 A1, ;
Page/Page column 62 ;
