1-甲氧基-2-萘酸甲酯合成路线 （共 19 条）
反应条件
in diethyl ether; dichloromethane T=-78°C;
参考文献
Journal of the American Chemical Society, , vol. 135, # 17 p. 6633 - 6642
反应条件
1.1: NaH / dimethylformamide 2.1: Mg / tetrahydrofuran / 1.5 h / Heating 2.2: 78 percent / tetrahydrofuran; benzene / 0 - 22 °C 3.1: 98 percent / KOH / ethanol / 24 h / Heating 4.1: Et3N; ethyl chloroformate / acetone / 0.5 h / -15 °C 4.2: 96 percent / NaN3 / acetone; H2O / 1.5 h / -15 °C 5.1: 96 percent / BBr3 / CH2Cl2 / 0 - 22 °C View Scheme
参考文献
Van Veldhuizen, Joshua J.; Garber, Steven B.; Kingsbury, Jason S.; Hoveyda, Amir H.
Journal of the American Chemical Society, 2002 , vol. 124, # 18 p. 4954 - 4955
反应条件
N,N-dimethyl-formamide T=50°C; 1.5 h;
参考文献
Hattori; Satoh; Miyano
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 12 p. 3840 - 3842
反应条件
1: 89 percent / aq.-ethanolic KOH / 1 h / Heating 2: SOCl2 / 3 h / Heating 3: 86 percent / 4-dimethylaminopyridine (DMAP), pyridine / benzene / 3 h / Heating View Scheme
参考文献
Hattori, Tetsutaro; Hotta, Hiroki; Suzuki, Takatsugu; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 2 p. 613 - 622
反应条件
T=50°C; 1.5 h; other naphthoates and benzoates, other sodium alkoxides, var. temp., var. time; Product distribution;
参考文献
Hattori; Satoh; Miyano
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 12 p. 3840 - 3842
反应条件
N,N-dimethyl-formamide T=50°C; 1.5 h;
参考文献
Hattori; Satoh; Miyano
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 12 p. 3840 - 3842
反应条件
T=50°C; 1.5 h; other naphthoates and benzoates, other sodium alkoxides, var. temp., var. time; Product distribution;
参考文献
Hattori; Satoh; Miyano
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 12 p. 3840 - 3842
反应条件
1.1: 91 percent / LiAlH4 / diethyl ether / 2 h / 20 °C 2.1: 100 percent / PBr3 / hexane; CH2Cl2 / 6 h / 20 °C 3.1: n-BuLi; diisopropylamine / tetrahydrofuran; cyclohexane / 1 h / -78 °C 3.2: 88 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; cyclohexane / 2 h / -78 °C 4.1: 83 percent / AlCl3 / chlorobenzene / 4 h / Heating View Scheme
参考文献
Kongkathip, Boonsong; Akkarasamiyo, Sunisa; Hasitapan, Komkrit; Sittikul, Pichamon; Boonyalai, Nonlawat; Kongkathip, Ngampong
European Journal of Medicinal Chemistry, 2013 , vol. 60, p. 271 - 284
反应条件
potassium carbonate in acetone
Reflux;
参考文献
Kongkathip, Ngampong; Pradidphol, Narathip; Hasitapan, Komkrit; Grigg, Ronald; Kao, Wei-Chun; Hunte, Carola; Fisher, Nicholas; Warman, Ashley J.; Biagini, Giancarlo A.; Kongsaeree, Palangpon; Chuawong, Pitak; Kongkathip, Boonsong
Journal of Medicinal Chemistry, 2010 , vol. 53, # 3 p. 1211 - 1221
反应条件
1: 1-hydroxy-naphthalene-2-carboxylic acid With potassium carbonate in acetone
0.25 h; Inert atmosphere;
2: dimethyl sulfate in acetone
T=55°C; 12 h; Inert atmosphere;
参考文献
Brockway, Anthony J.; Gonzalez-Lopez, Marcos; Fettinger, James C.; Shaw, Jared T.
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3515 - 3518
