DL-高半胱氨酸硫内酯盐酸盐合成路线 （共 9 条）
反应条件
salicylaldehyde in acetic acid T=5 - 50°C; 7 h; Product distribution / selectivity;
参考文献
EP1964838 A1, ;
Page/Page column 5 ;
反应条件
hydrogenchloride in water; acetone T=5°C; pH=1; 4 h; Product distribution / selectivity;
参考文献
EP1964838 A1, ;
Page/Page column 6 ;
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid T=20°C; Resolution of racemate; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 63 ;
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid T=20°C; Resolution of racemate; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 63 ;
反应条件
sodium hydroxide 0.5 h; Ambient temperature;
参考文献
Bregant, Sarah; Burlina, Fabienne; Chassaing, Gerard
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1047 - 1050
Title/Abstract Full Text View citing articles Show Details
Guerard, Christine; Breard, Maud; Courtois, Fabienne; Drujon, Thierry; Ploux, Olivier
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1661 - 1664
反应条件
triethylamine in chloroform Ambient temperature;
参考文献
Gobetti; Pedrazzoli; Bradamante
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 1 p. 69 - 79
反应条件
1: DL-homocysteine thiolactone hydrochloride With sodium hydrogencarbonate in 1,4-dioxane; water 0.5 h; Inert atmosphere; 2: di-tert-butyl dicarbonate in 1,4-dioxane; water Inert atmosphere;
参考文献
Llewellyn, David B.; Wahhab, Amal
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3939 - 3941
反应条件
triethylamine in dichloromethane T=0 - 20°C; 4.5 h;
参考文献
Yan, Jun-Jie; Wang, Di; Wu, De-Cheng; You, Ye-Zi
Chemical Communications, 2013 , vol. 49, # 54 p. 6057 - 6059
反应条件
sodium hydroxide in water
Ambient temperature;
参考文献
Musser, John H.; Bailey, Kevin; Suh, John T.
Heterocycles, 1985 , vol. 23, # 4 p. 889 - 894
