1 beta-呋喃核糖基-4-(甲硫基)吡唑并(3,4-d)嘧啶合成路线 （共 9 条）
反应条件
sodium in ethanol
18 h; Heating;
参考文献
Bhat; Montero; Panzica; Wotring; Townsend
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1165 - 1172
反应条件
1: 63 percent / H2O / 888 h / 35 °C / purine nucleoside phosphorylase, uridine phosphorylase, K2HPO4, NaN3
2: 1.) Dowex 1-X8 (HCO3-form) / 1.) methanol, heating, 2.) 24 deg C, 20 h
View Scheme
参考文献
Krenitsky; Rideout; Koszalka; Inmon; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 32 - 35
反应条件
1: 63 percent / H2O / 888 h / 35 °C / purine nucleoside phosphorylase, uridine phosphorylase, K2HPO4, NaN3
2: 1.) Dowex 1-X8 (HCO3-form) / 1.) methanol, heating, 2.) 24 deg C, 20 h
View Scheme
参考文献
Krenitsky; Rideout; Koszalka; Inmon; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 32 - 35
反应条件
1: 97 percent / thionyl chloride, DMF / CH2Cl2 / 14 h / 60 °C
2: 75 percent / sodium / ethanol / 18 h / Heating
View Scheme
参考文献
Bhat; Montero; Panzica; Wotring; Townsend
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1165 - 1172
反应条件
Dowex 1-X8 (HCO3-form)
1.) methanol, heating, 2.) 24 deg C, 20 h; Yield given. Multistep reaction;
参考文献
Krenitsky; Rideout; Koszalka; Inmon; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 32 - 35
参考文献
Rideout; Krenitsky; Koszalka; Cohn; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1040 - 1044
参考文献
Rideout; Krenitsky; Koszalka; Cohn; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1040 - 1044
反应条件
ammonium hydroxide; nickel in ethanol
T=135°C; 96 h; steel bomb;
参考文献
Bhat; Montero; Panzica; Wotring; Townsend
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1165 - 1172
反应条件
hydrazine in water
T=80°C; 3 h;
参考文献
Rideout; Krenitsky; Koszalka; Cohn; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1040 - 1044
