7-溴噻吩并[3,2-b]吡啶合成路线 （共 2 条）
反应条件
1: With phosphorus oxytribromide
T=69 - 100°C; 2 h;
2: With sodium hydroxide in water
pH=10 - 11;
参考文献
ELI LILLY AND COMPANY
Patent: WO2003/76442 A1, 2003 ;
Location in patent: Page/Page column 60 ;
WO 03/076442 A1
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h;
2: With water in tetrahydrofuran; methanol; hexane
T=20°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/36541 A1, 2008 ;
Location in patent: Page/Page column 25 ;
WO 2008/036541 A1
