2-氯-5-甲基-4-硝基吡啶-N-氧化物合成路线 （共 4 条）
反应条件
sulfuric acid; nitric acid T=100°C; 2 h;
参考文献
Abbot, Sarah C.; Billedeau, Roland J.; Dewdney, Nolan J.; Gabriel, Tobias; Goldstein, David M.; McCaleb, Kristen L.; Soth, Michael; Trejo-Martin, Teresa Alejandra; Zecic, Hasim
Heterocycles, 2009 , vol. 78, # 11 p. 2811 - 2826
反应条件
1: With dihydrogen peroxide in acetic anhydride T=20 - 60°C; 30.1667 h; Cooling with ice; 2: With sulfuric acid; nitric acid in acetic anhydride T=100°C; 1.5 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; Chau, Ryan W.; Cullis, Courtney A.; Duffey, Matthew O.; Gipson, Krista E.; Hu, Yongbo; Li, Gang; Sintchak, Michael D.; Vos, Tricia J.
Patent: US2013/165464 A1, 2013 ;
Location in patent: Paragraph 0843 ;
反应条件
in methanol Heating;
参考文献
Lorenc; Puszko
Chemistry of Heterocyclic Compounds, 1998 , vol. 34, # 5 p. 575 - 578
反应条件
iron; acetic acid T=100°C; 0.333333 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2003/91246 A1, 2003 ;
Location in patent: Page/Page column 49 ;
WO 03/091246 A1
