2-氟-4-甲氧基甲酰苯硼酸合成路线 (共 3 条)
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in acetonitrile T=160°C; 0.333333 h; Microwave;
参考文献
WO2005/32493 A2, ;
Page/Page column 44-45 ;
WO 2005/032493 A2
反应条件
1: 1,4-dibromo-2-fluorobenzene With n-butyllithium in diethyl ether; hexane T=-80°C; 0.5 h; Inert atmosphere; 2: With tri-isopropoxy-borane in tetrahydrofuran; diethyl ether; hexane T=-70°C; 0.5 h; Inert atmosphere; 3: carbonic acid dimethyl ester Further stages;
参考文献
Kurach, Pawel; Lulinski, Sergiusz; Serwatowski, Janusz
European Journal of Organic Chemistry, 2008 , # 18 p. 3171 - 3178
反应条件
sodium periodate; ammonium acetate in water; acetone T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 6 p. 1925 - 1944