4-氯-1H-吡咯并[3,2-c]吡啶合成路线 （共 6 条）
反应条件
manganese(IV) oxide in tetrahydrofuran Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/95223 A2, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
trichlorophosphate T=180°C; 5 h;
参考文献
Mahadevan,Indumathy; Rasmussen, Malcolm
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 359 - 367
反应条件
1: 79 percent / Na, liquid ammonia 2: 78 percent / phosphorus oxychloride / 5 h / 180 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 29, # 2 p. 359 - 367
反应条件
N-bromosuccinmide in dichloromethane T=0°C; 1 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/95223 A2, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); zinc in 1-methyl-pyrrolidin-2-one T=120°C; 18 h; Inert atmosphere;
参考文献
WO2013/92940 A1, ;
Page/Page column 38; 39 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Mahadevan,Indumathy; Rasmussen, Malcolm
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 359 - 367
