4-氨基-6-(三氯乙烯基)苯-1,3-二磺酰二氯合成路线 （共 10 条）
反应条件
1: aq. HNO3, H2SO4
2: SnCl2, aq. HCl / ethanol
3: (i) Ac2O, (ii) NO2/HNO3, (iii) (hydrolysis)
4: (i) NaNO2, aq. HCl, THF, (ii) SO2, CuCl, AcOH, (iii) NH3, CH2Cl2
5: Fe, aq. HCl / aq. ethanol
6: (i) ClSO3H, (ii) NH3, CH2Cl2
7: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
反应条件
1: SnCl2, aq. HCl / ethanol
2: (i) Ac2O, (ii) NO2/HNO3, (iii) (hydrolysis)
3: (i) NaNO2, aq. HCl, THF, (ii) SO2, CuCl, AcOH, (iii) NH3, CH2Cl2
4: Fe, aq. HCl / aq. ethanol
5: (i) ClSO3H, (ii) NH3, CH2Cl2
6: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
反应条件
1: Fe, aq. HCl / aq. ethanol
2: (i) ClSO3H, (ii) SOCl2, (iii) liq. SO2, CH2Cl2
3: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
反应条件
1: (i) Ac2O, (ii) NO2/HNO3, (iii) (hydrolysis)
2: (i) NaNO2, aq. HCl, THF, (ii) SO2, CuCl, AcOH, (iii) NH3, CH2Cl2
3: Fe, aq. HCl / aq. ethanol
4: (i) ClSO3H, (ii) NH3, CH2Cl2
5: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
反应条件
1: Zn / ethanol
2: (i) ClSO3H, (ii) SOCl2, (iii) liq. SO2, CH2Cl2
3: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
反应条件
1: Fe, aq. HCl / aq. ethanol
2: (i) ClSO3H, (ii) NH3, CH2Cl2
3: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
反应条件
1: (i) NaNO2, aq. HCl, THF, (ii) SO2, CuCl, AcOH, (iii) NH3, CH2Cl2
2: Fe, aq. HCl / aq. ethanol
3: (i) ClSO3H, (ii) NH3, CH2Cl2
4: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
反应条件
1: (i) ClSO3H, (ii) SOCl2, (iii) liq. SO2, CH2Cl2
2: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
反应条件
1: (i) ClSO3H, (ii) NH3, CH2Cl2
2: ClSO3H
View Scheme
参考文献
Mrozik; Bochis; Eskola; Matzuk; Waksmunski; Olen; Schwartzkopf Jr.; Grodski; Linn; Lusi; Wu; Shunk; Peterson; Milkowski; Hoff; Kulsa; Ostlind; Campbell; Riek; Harmon
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1225 - 1227
