3-{[3-乙酰氨基-5-羟基-6-(羟基甲基)-4-{[3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基]氧基}四氢-2H-吡喃-2-基]氧基}-2-氨基丁酸合成路线 （共 14 条）
反应条件
sodium methylate in methanol
T=5°C; pH = 10.5;
参考文献
Paulsen, Hans; Paal, Michael
Carbohydrate Research, 1984 , vol. 135, p. 71 - 84
反应条件
methanol; sodium methylate
T=0°C;
参考文献
Paulsen; Hoelck
Carbohydrate research, 1982 , vol. 109, p. 89 - 107
反应条件
β-galactosidase from bovine testes; sodium phosphate-citrate buffer in water
T=37°C; transglycosylation; pH=4.3; 48 h;
参考文献
Gambert, Ulrike; Thiem, Joachim
Carbohydrate Research, 1997 , vol. 299, # 1-2 p. 85 - 89
反应条件
1: 85 percent / molecular sieves 4 Angstroem / Ag2CO3/AgClO4 / toluene; CH2Cl2 / 8 h / 20 °C
2: 1.) NiCl2, NaBH4; 2.) pyridine / 1.) ethanol, 1 h; 2.) 6 h, 20 deg C
3: 87 percent / H2 / Pd/C / methanol / 6 h / 20 °C
4: 79 percent / sodium methoxide / methanol / 5 °C / pH = 10.5
View Scheme
参考文献
Paulsen, Hans; Paal, Michael
Carbohydrate Research, 1984 , vol. 135, p. 71 - 84
反应条件
1: 97 percent / TiBr4 / CH2Cl2; ethyl acetate / 6 h / 20 °C
2: 85 percent / molecular sieves 4 Angstroem / Ag2CO3/AgClO4 / toluene; CH2Cl2 / 8 h / 20 °C
3: 1.) NiCl2, NaBH4; 2.) pyridine / 1.) ethanol, 1 h; 2.) 6 h, 20 deg C
4: 87 percent / H2 / Pd/C / methanol / 6 h / 20 °C
5: 79 percent / sodium methoxide / methanol / 5 °C / pH = 10.5
View Scheme
参考文献
Paulsen, Hans; Paal, Michael
Carbohydrate Research, 1984 , vol. 135, p. 71 - 84
反应条件
1: 87 percent / H2 / Pd/C / methanol / 6 h / 20 °C
2: 79 percent / sodium methoxide / methanol / 5 °C / pH = 10.5
View Scheme
参考文献
Paulsen, Hans; Paal, Michael
Carbohydrate Research, 1984 , vol. 135, p. 71 - 84
反应条件
1: 81 percent / 1.) AgCO3, Drierite; 2.) AgClO4 / toluene; CH2Cl2 / 18 h
2: NiCl2*6H2O, H3BO3, NaBH4 / ethanol
3: pyridine
4: 71 percent / PhCH2ONa/PhCH2OH, molecular sieve / CH2Cl2 / 480 h
5: 70 percent / TsOH / acetonitrile
6: 53 percent / Hg(CN)2, HgBr2 / nitromethane; toluene
7: 95 percent / H2 / 9.7percent Pd-C / acetic acid; methanol / 18 h / Ambient temperature
8: 87 percent / NaOMe/MeOH / 0 °C
View Scheme
参考文献
Paulsen; Hoelck
Carbohydrate research, 1982 , vol. 109, p. 89 - 107
反应条件
1: 70 percent / TsOH / acetonitrile
2: 53 percent / Hg(CN)2, HgBr2 / nitromethane; toluene
3: 95 percent / H2 / 9.7percent Pd-C / acetic acid; methanol / 18 h / Ambient temperature
4: 87 percent / NaOMe/MeOH / 0 °C
View Scheme
参考文献
Paulsen; Hoelck
Carbohydrate research, 1982 , vol. 109, p. 89 - 107
反应条件
1: 53 percent / Hg(CN)2, HgBr2 / nitromethane; toluene
2: 95 percent / H2 / 9.7percent Pd-C / acetic acid; methanol / 18 h / Ambient temperature
3: 87 percent / NaOMe/MeOH / 0 °C
View Scheme
参考文献
Paulsen; Hoelck
Carbohydrate research, 1982 , vol. 109, p. 89 - 107
反应条件
1: 71 percent / PhCH2ONa/PhCH2OH, molecular sieve / CH2Cl2 / 480 h
2: 70 percent / TsOH / acetonitrile
3: 53 percent / Hg(CN)2, HgBr2 / nitromethane; toluene
4: 95 percent / H2 / 9.7percent Pd-C / acetic acid; methanol / 18 h / Ambient temperature
5: 87 percent / NaOMe/MeOH / 0 °C
View Scheme
参考文献
Paulsen; Hoelck
Carbohydrate research, 1982 , vol. 109, p. 89 - 107
