1,2,5,6-四氢吡啶-3-羧酸盐酸盐合成路线 （共 2 条）
反应条件
1: With potassium carbonate in water 2: With 1-chloroethyl chlorocarbonate in toluene 12 h; Reflux;
参考文献
US2009/258883 A1, ;
Page/Page column 12 ;
US 20090258883 A1
反应条件
1: guvacine hydrochloride With sodium hydroxide in tert-butyl alcohol T=5 - 10°C; deprotonation; 2: di-tert-butyl dicarbonate in tert-butyl alcohol T=20°C; Substitution;
参考文献
Guo, Zhengming; Zheng, Xiaozhang; Thompson, Walter; Dugdale, Marion; Gollamudi, Ram
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 1041 - 1058
