反应条件
1: 2.) TBHP, D(-)DIPT, Ti(OiPr)4 / 1.) -78 deg C, THF; 2.) CH2Cl2, -21 deg C, 20 h 2: Br2 / CH2Cl2 / 0 °C 3: nBu4NF / tetrahydrofuran / 0 °C 4: imidazole / dimethylformamide / 0 - 20 °C 5: 94 percent / Pd(PPh3)4, CuI, nPrNH2 / benzene / 20 °C 6: 90 percent / KCN, AgNO3, / ethanol; tetrahydrofuran; H2O / 0 °C 7: 1.) disiamylborane, 2.) aq. 2N NaOH, Pd(PPh3)4 / 1.) THF,0 deg C, 1h; 2.) 50 deg C, 16 h 8: 80 percent / nBu4NF / tetrahydrofuran / 18 h / 25 °C View Scheme
参考文献
Kobayashi, Yuichi; Shimazaki, Toshiyuki; Taguchi, Hideki; Sato, Fumie
Journal of Organic Chemistry, 1990 , vol. 55, # 19 p. 5324 - 5335
