(2-羟基苯基)二苯基膦合成路线 （共 16 条）
反应条件
sodium acetate; palladium diacetate in N,N-dimethyl acetamide
T=110°C; 16 h; Inert atmosphere;
参考文献
Kapadnis, Prashant B.; Hall, Evan; Ramstedt, Madeleine; Galloway, Warren R. J. D.; Welch, Martin; Spring, David R.
Chemical Communications, 2009 , # 5 p. 538 - 540
反应条件
hydrogenchloride; methanol
1 h;
参考文献
Bianchi, Aldo; Bernardi, Anna
Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2231 - 2234
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Bianchi, Aldo; Bernardi, Anna
Journal of Organic Chemistry, 2006 , vol. 71, # 12 p. 4565 - 4577
反应条件
toluene-4-sulfonic acid in methanol
4.5 h;
参考文献
Blume, Florian; Zemolka, Saskia; Fey, Thorsten; Kranich, Remo; Schmalz, Hans-Guenther
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 8 p. 868 - 883
反应条件
1.1: n-BuLi; TMEDA / diethyl ether; hexane; cyclohexane / -60 - 20 °C
1.2: 72 percent / diethyl ether; hexane; cyclohexane / 16 h / -70 - 20 °C
2.1: 99 percent / diethyl ether; cyclohexane / 24 h / -80 - 20 °C
3.1: 88 percent / pyridinium p-toluenesulfonate / ethanol; CH2Cl2 / 4 h / 65 °C
View Scheme
参考文献
Mueller, Christian; Ackerman, Lily J.; Reek, Joost N. H.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
Journal of the American Chemical Society, 2004 , vol. 126, # 45 p. 14960 - 14963
反应条件
1.1: 82 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 2.5 h
2.1: n-BuLi; TMEDA / diethyl ether; hexane; cyclohexane / -60 - 20 °C
2.2: 72 percent / diethyl ether; hexane; cyclohexane / 16 h / -70 - 20 °C
3.1: 99 percent / diethyl ether; cyclohexane / 24 h / -80 - 20 °C
4.1: 88 percent / pyridinium p-toluenesulfonate / ethanol; CH2Cl2 / 4 h / 65 °C
View Scheme
参考文献
Mueller, Christian; Ackerman, Lily J.; Reek, Joost N. H.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
Journal of the American Chemical Society, 2004 , vol. 126, # 45 p. 14960 - 14963
反应条件
1: 99 percent / diethyl ether; cyclohexane / 24 h / -80 - 20 °C
2: 88 percent / pyridinium p-toluenesulfonate / ethanol; CH2Cl2 / 4 h / 65 °C
View Scheme
参考文献
Mueller, Christian; Ackerman, Lily J.; Reek, Joost N. H.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
Journal of the American Chemical Society, 2004 , vol. 126, # 45 p. 14960 - 14963
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: 61 percent / tetrahydrofuran / -78 - 20 °C
2.1: 70 percent / p-TsOH / methanol / 4.5 h
View Scheme
参考文献
Blume, Florian; Zemolka, Saskia; Fey, Thorsten; Kranich, Remo; Schmalz, Hans-Guenther
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 8 p. 868 - 883
反应条件
1.1: n-BuLi; TMEDA / hexane / 1.5 h / 20 °C
1.2: 61 percent / hexane / 16 h / 20 °C
2.1: 77 percent / HCl / methanol / 1 h / 20 °C
View Scheme
参考文献
Bianchi, Aldo; Bernardi, Anna
Journal of Organic Chemistry, 2006 , vol. 71, # 12 p. 4565 - 4577
反应条件
1: With boron tribromide
2: With methanol
参考文献
Suarez, Andres; Pizzano, Antonio
Tetrahedron Asymmetry, 2001 , vol. 12, # 18 p. 2501 - 2504
反应条件
palladium diacetate in N,N-dimethyl acetamide
T=100°C; 6 h; Inert atmosphere;
参考文献
Mamat, Constantin; Flemming, Anke; Koeckerling, Martin; Steinbach, Joerg; Wuest, Frank R.
Synthesis, 2009 , # 19 p. 3311 - 3321
