6-甲氧基-2,6-二氢-3H-吡喃-3-酮合成路线 （共 10 条）
反应条件
1: 82 percent / Br2; Et3N / CH2Cl2 / 2 h / 20 °C 2: CF3COOH / 2 h / Heating View Scheme
参考文献
Liu, Zu D.; Khodr, Hicham H.; Liu, Ding Y.; Lu, Shu L.; Hider, Robert C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 23 p. 4814 - 4823
反应条件
1: 90 percent / LiAlH4 / diethyl ether / 0.5 h / -60 °C 2: 72 percent / NBS; Me2S / CH2Cl2 / 1 h / 0 °C 3: 90 percent / Jones reagent / acetone / 0.5 h 4: 70 percent / Et3N / 0.5 h / Heating View Scheme
参考文献
Kotretsou, Stamatia I.; Georgiadis, Minas P.
Organic Preparations and Procedures International, 2000 , vol. 32, # 2 p. 161 - 167
反应条件
1: 90 percent / LiAlH4 / diethyl ether / 0.5 h / -60 °C 2: 72 percent / NBS; Me2S / CH2Cl2 / 1 h / 0 °C 3: 90 percent / Jones reagent / acetone / 0.5 h 4: 65 percent / (PhCO2)2; NBS / CCl4 / 4 h / Heating 5: 90 percent / Et3N / 0.5 h / Heating View Scheme
参考文献
Kotretsou, Stamatia I.; Georgiadis, Minas P.
Organic Preparations and Procedures International, 2000 , vol. 32, # 2 p. 161 - 167
反应条件
1: 90 percent / LiAlH4 / diethyl ether / 0.5 h / -60 °C 2: 72 percent / NBS; Me2S / CH2Cl2 / 1 h / 0 °C 3: 90 percent / Jones reagent / acetone / 0.5 h 4: 65 percent / Br2 / CHCl3 / 1 h / Heating 5: 90 percent / Et3N / 0.5 h / Heating View Scheme
参考文献
Kotretsou, Stamatia I.; Georgiadis, Minas P.
Organic Preparations and Procedures International, 2000 , vol. 32, # 2 p. 161 - 167
参考文献
Brescia, Marc-Raleigh; Shimshock, Yvonne Class; DeShong, Philip
Journal of Organic Chemistry, 1997 , vol. 62, # 5 p. 1257 - 1263
反应条件
formic acid in methanol
hydrolysis; ring expansion;
参考文献
Liu, Zu D.; Khodr, Hicham H.; Liu, Ding Y.; Lu, Shu L.; Hider, Robert C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 23 p. 4814 - 4823
反应条件
ZnCl2*Et2O in dichloromethane; 1,2-dichloro-ethane
参考文献
Mucha, Bernd; Hoffmann, H.Martin R.
Tetrahedron Letters, 1989 , vol. 30, # 34 p. 4489 - 4492
反应条件
1: 72.2 percent / NaHCO3; Br2 / 2 h / 20 °C
2: 84.4 percent / HCOOH / methanol
View Scheme
参考文献
Liu, Zu D.; Khodr, Hicham H.; Liu, Ding Y.; Lu, Shu L.; Hider, Robert C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 23 p. 4814 - 4823
参考文献
Lopez-Tudanca, Pedro L.; Jones, Keith; Brownbridge, Peter
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 5 p. 533 - 534
反应条件
1: benzene / 16 h / Heating
2: triethylamine / CH2Cl2 / 2 h / Ambient temperature
3: 50 percent / 5percent palladium on carcoal / toluene / 0.5 h / Heating
View Scheme
参考文献
Sammes, Peter G.; Whitby, Richard J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 195 - 202
