1-(1-苯基环己基)-4-羟基哌啶合成路线 （共 12 条）
反应条件
ammonium chloride; iodine; magnesium in tetrahydrofuran; methanol; chloroform
参考文献
Abbott Laboratories
Patent: US5124457 A1, 1992 ;
反应条件
in tetrahydrofuran
1.) reflux, 2 h, 2.) 22 deg C;
参考文献
Al-Deeb
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 10 p. 1141 - 1144
反应条件
oxygen; tetrasodium ethylenediaminetetraacetate; iron(II) sulfate; isoascorbic acid in water
T=37°C; 1 h; sodium phosphate buffer; var. reag.: Fe(III)TPPCl with iodosylxylene, or cumenehydroperoxide or O2/Zn/AcOH; Yield given. Further byproducts given;
参考文献
Masumoto; Takeuchi; Ohta; Hirobe
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 7 p. 1788 - 1794
反应条件
1: 1.) hydrochloric acid / 1.) water, 2.) water, 24 h
2: 85 percent / tetrahydrofuran / 1.) reflux, 2 h, 2.) 22 deg C
View Scheme
参考文献
Al-Deeb
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 10 p. 1141 - 1144
反应条件
1: 1.) hydrochloric acid / 1.) water, 2.) water, 24 h
2: 85 percent / tetrahydrofuran / 1.) reflux, 2 h, 2.) 22 deg C
View Scheme
参考文献
Al-Deeb
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 10 p. 1141 - 1144
反应条件
1: 30 g / hexamethyldisilazane, pyridine / 1 h / Ambient temperature
2: 1.) Mg / 1.) ether, 2.) benzene, reflux, 5 h
View Scheme
参考文献
Itzhak, Yossef; Kalir, Asher; Weissman, Ben Avi; Cohen, Sasson
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 496 - 499
反应条件
magnesium
1.) ether, 2.) benzene, reflux, 5 h; Yield given. Multistep reaction;
参考文献
Itzhak, Yossef; Kalir, Asher; Weissman, Ben Avi; Cohen, Sasson
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 496 - 499
反应条件
in water
312 h; Ambient temperatureBeauveria sulfurescens; Title compound not separated from byproducts;
参考文献
Hufford; Baker; Clark
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 2 p. 155 - 158
反应条件
in water
microsomal fractions of rabbit liver; Title compound not separated from byproducts;
参考文献
Addison, J. B.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 3 p. 215 - 217
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 3 p. 110 - 113
反应条件
in water
Ambient temperatureCunninghamella echinulata; metabolism by microorganisms; further microbial agents;
参考文献
Hufford; Baker; Clark
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 2 p. 155 - 158
