3-羟基-2-硝基苯甲酸合成路线 （共 44 条）
反应条件
1: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature
2: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, overnight
3: aq. HCl / acetone / 6 h / Ambient temperature
4: Fe, AcOH / methanol / 2 h / Heating
View Scheme
参考文献
Kaneko; Wong; Doyle; Rose; Bradner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 388 - 392
反应条件
1: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature
2: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, overnight
3: aq. HCl / acetone / 6 h / Ambient temperature
4: Fe, AcOH / methanol / 2 h / Heating
View Scheme
参考文献
Kaneko; Wong; Doyle; Rose; Bradner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 388 - 392
反应条件
1: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature
2: 1.) LDA / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 0.5 h, b) RT, 1,5 h
View Scheme
参考文献
Kaneko; Wong; Doyle; Rose; Bradner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 388 - 392
反应条件
1: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature
2: 1.) LDA / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 0.5 h, b) RT, 1,5 h
View Scheme
参考文献
Kaneko; Wong; Doyle; Rose; Bradner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 388 - 392
反应条件
1: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature
2: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, overnight
View Scheme
参考文献
Kaneko; Wong; Doyle; Rose; Bradner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 388 - 392
反应条件
1: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature
2: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, overnight
View Scheme
参考文献
Kaneko; Wong; Doyle; Rose; Bradner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 388 - 392
反应条件
1: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature
2: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, overnight
View Scheme
参考文献
Kaneko; Wong; Doyle; Rose; Bradner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 388 - 392
反应条件
hydrogen; p-benozquinone; palladium on activated charcoal
1.) methanol, 2.) methanol, 18-20 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Korshunova, Z. I.; Popova, E. B.; Glibin, E. N.; Ginzburg, O. F.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 2.2 p. 314 - 319
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 2 p. 369 - 376
反应条件
hydrogen; p-benozquinone; palladium on activated charcoal
1.) methanol, 2.) methanol, 18-20 deg C, 16 h; Multistep reaction;
参考文献
Korshunova, Z. I.; Popova, E. B.; Glibin, E. N.; Ginzburg, O. F.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 2.2 p. 314 - 319
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 2 p. 369 - 376
反应条件
1: Raney nickel; ethanol / Hydrogenation
2: yellow HgO; aqueous NH3
View Scheme
参考文献
Butenandt et al.
Justus Liebigs Annalen der Chemie, 1957 , vol. 602, p. 72,79
