2-(2,3,5-三-O-苯甲酰基-beta-D-呋喃核糖基)-4-噻唑羧酸乙酯合成路线 （共 10 条）
反应条件
ammonia in methanol T=20°C; 24 h;
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
参考文献
Fuertes; Garcia Lopez; Garcia Munoz; Stud
Journal of Organic Chemistry, 1976 , vol. 41, # 26 p. 4074 - 4077
反应条件
1: 71 percent / triethylamine / methanol / 2 h / 20 °C
2: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C
View Scheme
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
反应条件
1: 69 percent / stannic chloride / CH2Cl2 / 3 h / Heating
2: 71 percent / triethylamine / methanol / 2 h / 20 °C
3: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C
View Scheme
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
反应条件
1: 95 percent / AcOH; H2SO4 / 0.5 h / 20 °C
2: 69 percent / stannic chloride / CH2Cl2 / 3 h / Heating
3: 71 percent / triethylamine / methanol / 2 h / 20 °C
4: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C
View Scheme
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
反应条件
1: 89 percent / DMAP; pyridine / 50 °C
2: 95 percent / AcOH; H2SO4 / 0.5 h / 20 °C
3: 69 percent / stannic chloride / CH2Cl2 / 3 h / Heating
4: 71 percent / triethylamine / methanol / 2 h / 20 °C
5: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C
View Scheme
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
反应条件
1: 87 percent / Dowex 50H+ / methanol / 48 h / 60 °C
2: 89 percent / DMAP; pyridine / 50 °C
3: 95 percent / AcOH; H2SO4 / 0.5 h / 20 °C
4: 69 percent / stannic chloride / CH2Cl2 / 3 h / Heating
5: 71 percent / triethylamine / methanol / 2 h / 20 °C
6: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C
View Scheme
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
反应条件
1: 92 percent / pyridine / 5 h / 20 °C
2: 87 percent / Dowex 50H+ / methanol / 48 h / 60 °C
3: 89 percent / DMAP; pyridine / 50 °C
4: 95 percent / AcOH; H2SO4 / 0.5 h / 20 °C
5: 69 percent / stannic chloride / CH2Cl2 / 3 h / Heating
6: 71 percent / triethylamine / methanol / 2 h / 20 °C
7: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C
View Scheme
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
反应条件
1: 92 percent / pyridine / 5 h / 20 °C
2: 87 percent / Dowex 50H+ / methanol / 48 h / 60 °C
3: 89 percent / DMAP; pyridine / 50 °C
4: 95 percent / AcOH; H2SO4 / 0.5 h / 20 °C
5: 69 percent / stannic chloride / CH2Cl2 / 3 h / Heating
6: 71 percent / triethylamine / methanol / 2 h / 20 °C
7: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C
View Scheme
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
参考文献
Srivastava; Pickering; Allen; Streeter; Campbell; Witkowski; Sidwell; Robins
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 256 - 262
