4-溴-3-甲基-5-(三氟甲基)-1H-吡唑合成路线 （共 3 条）
反应条件
bromine; sodium acetate; acetic acid T=0 - 20°C; 21.1667 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/141020 A1, 2008 ;
Location in patent: Page/Page column 51 ;
WO 2008/141020 A1
反应条件
1.1: hydrazine / dioxane 1.2: toluene / Heating 2.1: 99 percent / N-bromosuccinimide / dimethylformamide / 1 h / 25 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 128, # 10 p. 1191 - 1197
反应条件
potassium carbonate in acetone T=25°C; 1.5 h;
参考文献
Journal of Fluorine Chemistry, , vol. 128, # 10 p. 1191 - 1197
