3,4-亚甲二氧基苯乙醇合成路线 （共 17 条）
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=25 - 30°C; 1.25 h;
参考文献
Boehm; Gleason; Pendrak; Sarau; Schmidt; Foley; Kingsbury
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3333 - 3340
反应条件
in tetrahydrofuran; water
参考文献
Texas Biotechnology Corporation
Patent: US5962490 A1, 1999 ;
US 5962490 A
参考文献
Pfizer Inc.
Patent: US5397800 A1, 1995 ;
反应条件
1: With ozone in dichloromethane T=-10°C; 4 h; 2: With sodium tetrahydroborate in methanol T=0°C; 2 h;
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
ethanol; nickel T=40°C; P=29420.3 Torr;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 6, p. 574
Yakugaku Zasshi, , vol. 71, p. 1159
Chem.Abstr., , p. 5049
反应条件
1: 87 percent / LDA / -78 °C 2: 89 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 0.33 h / 0 °C 3: 82 percent / Bu3SH; AIBN / benzene / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 13 p. 2121 - 2124
反应条件
1: 89 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 0.33 h / 0 °C 2: 82 percent / Bu3SH; AIBN / benzene / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 13 p. 2121 - 2124
参考文献
Monatshefte fuer Chemie, , vol. 27, p. 238
反应条件
1.1: tin(IV) chloride / 0 - 25 °C / Inert atmosphere 2.1: acetyl chloride / 4 h / Inert atmosphere; Reflux 2.2: 1 h / 90 - 100 °C / Inert atmosphere 3.1: titanium tetraethoxide / dichloromethane / 4 h / Reflux; Inert atmosphere 4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 4.2: -78 - 20 °C / Inert atmosphere 5.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere 6.1: trifluoroacetic acid / toluene / 0.5 h / 140 °C / Microwave irradiation 6.2: pH 8 View Scheme
参考文献
Mastranzo, Virginia M.; Olivares Romero, Jose Luis; Yuste, Francisco; Ortiz, Benjamin; Sanchez-Obregon, Ruben; Garcia Ruano, Jose L.
Tetrahedron, 2012 , vol. 68, # 4 p. 1266 - 1271
反应条件
triethylamine in dichloromethane
参考文献
Kende; Andrew S.; Liebeskind; Lanny S.
Patent: US4003916 A1, 1977 ;
