(4-氨基苯氧基)乙酸甲酯合成路线 （共 8 条）
反应条件
hydrogen; 10percent Pd/C in methanol T=20°C; Reduction; 6 h;
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
trifluoroacetic acid in 1,4-dioxane T=20°C; 1 h;
参考文献
MERCK PATENT GMBH
Patent: WO2003/103567 A2, 2003 ;
Location in patent: Page 33-34 ;
反应条件
hydrogenchloride T=10°C; 11 h; Heating / reflux;
参考文献
BEZWADA BIOMEDICAL, LLC
Patent: US2009/170927 A1, 2009 ;
Location in patent: Page/Page column 27 ;
反应条件
1: 75 percent / K2CO3 / dimethylformamide / 48 h / 20 °C 2: 98 percent / H2 / 10percent Pd/C / methanol / 6 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3052 - 3066
参考文献
Journal of the American Chemical Society, , vol. 39, p. 2190
反应条件
1.1: thionyl chloride / 0.17 h / -10 °C 1.2: 1 h 2.1: 5 Pd(II)/C(eggshell); hydrogen / methanol / 12 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 17 p. 6463 - 6480
反应条件
1.1: aq. NaNO2; aq. HBr / methanol; acetone / 0.5 h 1.2: CuBr / methanol; acetone / 20 °C 2.1: 2.5 h / Heating 2.2: aq. HCl / 5 h / Heating View Scheme
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
参考文献
Jacobs; Heidelberger
Journal of the American Chemical Society, 1917 , vol. 39, p. 2437
