5-叔丁基呋喃-2-羧酸甲酯合成路线 （共 10 条）
反应条件
hydrogen; palladium 10 on activated carbon in 2-ethoxy-ethanol P=2068.65 Torr; 1 h;
参考文献
Bayer Corporation
Patent: EP1019040 B1, 2004 ;
Location in patent: Page/Page column 28 ;
反应条件
carbon disulfide; aluminium trichloride
参考文献
Hurd; Oliver
Journal of the American Chemical Society, 1954 , vol. 76, p. 50
Full Text View citing articles Show Details
Gilman; Calloway
Journal of the American Chemical Society, 1933 , vol. 55, p. 4197,4200
反应条件
1: 5-tert-butylfuran-2-carboxylic acid With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: With 4-toluenesulfonyl azide in tetrahydrofuran; hexane
T=-78 - 0°C; 2 h;
3: diazomethyl-trimethyl-silane With potassium acetate
more than 3 stages;
参考文献
Bayer Pharmaceuticals Corporation; ONYX PHARMACEUTICALS, INC.
Patent: EP986382 B1, 2008 ;
Location in patent: Page/Page column 13; 22-23 ;
EP 0986382 B1
反应条件
1: C9H11N3O3 With 4-toluenesulfonyl azide; potassium hydrogencarbonate in tetrahydrofuran; hexane
T=0 - 20°C; 16 h;
2: diazomethyl-trimethyl-silane in methanol; hexane; ethyl acetate
0.5 h;
参考文献
Bayer Corporation
Patent: EP1019040 B1, 2004 ;
Location in patent: Page/Page column 27-28 ;
参考文献
Bayer Corporation
Patent: US6344476 B1, 2002 ;
US 6344476 B1
反应条件
carbon disulfide; aluminium trichloride
参考文献
Hurd; Oliver
Journal of the American Chemical Society, 1954 , vol. 76, p. 50
Full Text View citing articles Show Details
Gilman; Calloway
Journal of the American Chemical Society, 1933 , vol. 55, p. 4197,4200
反应条件
carbon disulfide; aluminium trichloride
参考文献
Hurd; Oliver
Journal of the American Chemical Society, 1954 , vol. 76, p. 50
Full Text View citing articles Show Details
Gilman; Calloway
Journal of the American Chemical Society, 1933 , vol. 55, p. 4197,4200
反应条件
carbon disulfide; iron(III) chloride
参考文献
Gilman; Calloway
Journal of the American Chemical Society, 1933 , vol. 55, p. 4197,4200
参考文献
Hurd; Oliver
Journal of the American Chemical Society, 1954 , vol. 76, p. 50
反应条件
1: 76 percent / ZnCl2; HCl / CCl4 / 2 h / 55 - 60 °C
2: 84 percent / acetic acid / 13 h / 130 °C
3: 5.2 g / KOH / H2O / 6 h / Heating
4: 10.5 g / thionyl chloride / benzene / 6 h / Heating
5: 4 g / aq.NH3 / dioxane; H2O / cooling
View Scheme
参考文献
Pevzner
Russian Journal of General Chemistry, 2003 , vol. 73, # 11 p. 1715 - 1724
