1,4-二氢-4-beta-D-呋喃核糖基-5H-1,2,3-三唑并[4,5-b]吡啶-5-酮合成路线 （共 6 条）
反应条件
sodium azide in N,N-dimethyl-formamide T=110 - 120°C; 12 h;
参考文献
Wang, Peiyuan; Hollecker, Laurent; Pankiewicz, Krzysztof W.; Patterson, Steven E.; Whitaker, Tony; McBrayer, Tamara R.; Tharnish, Phillip M.; Stuyver, Lieven J.; Schinazi, Raymond F.; Otto, Michael J.; Watanabe, Kyoichi A.
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 957 - 960
反应条件
1: 81 percent / NH3 / methanol / 20 °C 2: 60 percent / sodium azide / dimethylformamide / 12 h / 110 - 120 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 957 - 960
反应条件
1: 70 percent / SnCl4 / 1,2-dichloro-ethane 2: 81 percent / NH3 / methanol / 20 °C 3: 60 percent / sodium azide / dimethylformamide / 12 h / 110 - 120 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 957 - 960
反应条件
1: 15.53 g / SnCl4 / 1,2-dichloro-ethane; CH2Cl2 / 8 °C / Heating 2: 81 percent / NH3 / methanol / 12 h / 20 °C 3: 60 percent / NaN3 / dimethylformamide / 12 h / 110 - 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 24 p. 6100 - 6103
反应条件
1: ammonium sulfate / 6 h / Heating 2: 15.53 g / SnCl4 / 1,2-dichloro-ethane; CH2Cl2 / 8 °C / Heating 3: 81 percent / NH3 / methanol / 12 h / 20 °C 4: 60 percent / NaN3 / dimethylformamide / 12 h / 110 - 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 24 p. 6100 - 6103
反应条件
1: 70 percent / SnCl4 / 1,2-dichloro-ethane 2: 81 percent / NH3 / methanol / 20 °C 3: 60 percent / sodium azide / dimethylformamide / 12 h / 110 - 120 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 957 - 960
