durch enzymatische Reduktion;

dihydroorotate dehydrogenase; bis(1-chloro-2-propyl)-ether; All-Trans Coenzyme Q6; Triton X-100 in water T=37°C; pH=7.8;

1: 59 percent / Et3N / dimethylformamide / 48 h / Ambient temperature 2: 60 percent / NaH (60percent in oil) / dimethylformamide / 0.5 h / 25 °C View Scheme

1: 59 percent / Et3N / dimethylformamide / 48 h / Ambient temperature 2: 60 percent / NaH (60percent in oil) / dimethylformamide / 0.5 h / 25 °C 3: 73 percent / hydrogen / 5percent Pd/C / ethanol / 2 h View Scheme

triethylamine in N,N-dimethyl-formamide 48 h; Ambient temperature;